Tripterygium wilfordii Hook.f. - syn. Tripterygium hypoglaucum (H.Léveillé) Hutchinson; Aspidopterys hypoglauca H.Léveillé - Celastraceae
雷公藤 lei gong teng (chin.), thunder god vine, Wilfords Dreiflügelfrucht

Deciduous subshrubs or sometimes semiwoody vine, 2-10m, native to China, Japan, Korea, NE Myanmar; leaves ovate or rounded-ovate, sometimes oblong or elliptic-ovate, margin entire or less often crenulate; thyrses large, composed of several to dozens of thyrselets; flowers normal and as unfertilized male, whitish, greenish, or yellow-green, small, 4-6mm, calyx 5-lobed, petals 5, stamens 5, stigma bright purple; samara usually green or greenish brown when mature, sometimes pink or pinkish purple.

Used in traditional Chinese medicine for relieving autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus, and for treating cancer.

„… Celastrol, a pentacyclic triterpene extracted from the roots of Tripterygium Wilfordi (thunder god vine) plant, is a powerful anti-obesity agent. Celastrol suppresses food intake, blocks reduction of energy expenditure, and leads to up to 45% weight loss in hyperleptinemic diet-induced obese (DIO) mice by increasing leptin sensitivity, but it is ineffective in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mouse models. These results indicate that Celastrol is a leptin sensitizer and a promising agent for the pharmacological treatment of obesity.“
[Treatment of obesity with celastrol., Liu, J., Lee, J., Hernandez, M.A.S., Mazitschek, R., Ozcan, U., Cell, 161(5), 2015, 999-1011]
Celastrol action (C)

Picture: Flora of China @

tripterygium_wilfordii_hook.f.txt · Zuletzt geändert: 2016/10/28 09:40 von andreas