Orthosiphon aristatus (Blume) Miquel - Orthosiphon spicatus (Thunb.) Backer; Orthosiphon stamineus Benth. - Lamiaceae
cat's-whiskers, whiskerplant, Java-tea, Katzenbart, Orthosiphon

Perennial herb, native to Southeast Asia and northern Australia, cultivated elsewhere as ornamental; leaves with ovate to rhombic, coarsely toothed; flowers showy, white to pale lavender or lilac, stamens 5-6 cm long that look like cat’s whiskers.

„Orthosiphon aristatus [leaves] (Orthosiphonis folium DAB 9) was studied with regard to its phenolic constituents. Twenty compounds were isolated and identified on the basis of their spectral characteristics. The compounds included nine lipophilic flavones, two flavonol glycosides, and nine caffeic acid derivatives. The presence of the recently reported methylripariochromene A could not be confirmed. All compounds identified were quantified by HPLC. The caffeic acid derivatives including the major compounds rosmarinic acid and 2,3-dicaffeoyltartaric acid (67% of total identified phenolics) predominated over the flavones (33%) in an aqueous MeOH extract. The predominance of the caffeic acid derivatives was even more pronounced in a hot water extract (94.5% of total identified phenolics) that was comparable to a herbal tea.“
[Qualitative and Quantitative Analysis of the Phenolic Constituents from Orthosiphon aristatus., Sumaryono, W., Proksch, P., Wray, V., Witte, L., Hartmann, T., Planta medica, Vol.(57), 1991, 176-80]

„Orthosiphon stamineus (Labiatae) is a traditional folk medicine widely used in Southeast Asia for the treatment of several kidney disorders, gout and as a diuretic… The diuretic effect of different methanol extracts was examined by treating different groups of Sprague–Dawley rats with single (2 g/kg) oral doses of methanol and methanol:water (1:1) extracts… Sodium and potassium excretion increased significantly (p < 0.05 and <0.01) in the first 8 h of treatment with a single dose (2 g/kg) of the extracts in a pattern comparable to that of the known diuretic hydrochlorothiazide. Meanwhile, repeated administration of 0.5 g/kg methanol:water (1:1) extract showed a significant increase in urine volume (from day 3 to day 7) (p < 0.01) and electrolytes excretion (Na+ and K+) from day 2 to day 7 (p < 0.05 and <0.01). On the other hand, 0.5, 1 and 2 g/kg of methanol:water (1:1) extract and the standard allopurinol reduced the serum urate level in hyperuricemic rats at hour 6.“
[Studies on diuretic and hypouricemic effects of Orthosiphon stamineus methanol extracts in rats., Arafat, O.M., Tham, S.Y., Sadikun, A., Zhari, I., Haughton, P.J., Asmawi, M.Z., Journal of ethnopharmacology, Vol.118(3), 2008, 354-360]

„Orthosiphon stamineus Benth. ( Orthosiphon Grandiflorus Bold. or Clerodendranthus spicatus Thunb.) is an Indonesian medicinal herb traditionally used for diseases such as hypertension, diabetes, and kidney stones… A bioassay-guided fractionation of a methanol-water extract of Orthosiphon stamineus leaves using the adenosine A (1) receptor binding assay resulted in the isolation of seven methoxy flavonoids as active ligands with K(i) values in the micromolar range. The Hill slope values are not significantly different from unity (within 0.9 - 1.4), which indicates the antagonist effect to A (1)-R. The results of this study thus provide a scientific foundation for the traditional use of Orthosiphon stamineus in kidney stone treatment, as the affinity of the active compounds isolated from it as adenosine A (1) receptor ligands allows them to be associated with diuretic activity, which is one possible treatment for renal lithiasis.“
[Adenosine A1 receptor binding activity of methoxy flavonoids from Orthosiphon stamineus., Yuliana, N.D., Khatib, A., Link-Struensee, A.M., Ijzerman, A.P., Rungkat-Zakaria, F., Choi, Y.H., Verpoorte, R., Planta medica, Vol.75(2), 2009, 132-136]

Orthosiphon aristatus (Blume) Miq. [as Orthosiphon stamineus Benth.]
Curtis’s Botanical Magazine, vol. 96 [ser. 3, vol. 26]: t. 5833 (1870) [W.H. Fitch]

orthosiphon_aristatus_blume_miq.txt · Zuletzt geändert: 2015/06/13 11:39 (Externe Bearbeitung)