Marsdenia cundurango Rchb. f. - syn.Marsdenia reichenbachii Triana - Asclepiadaceae
condurango, condorvine, Kondurango, Andenwein, Kondorliane
Evergreen vine, native to north-western South America; leaves heart-shaped; flowers small, greenish white.
The dried bark (Condurango cortex) is used as digestive (bitter tonic) to stimulate appetite and traditionally in case of liver and menstrual disorders. The bark contains a complex mixture of pregnane ester genins (condurangogenines) and their glycosides.
[Medicinal Plants of the World. Ben-Erik Van Wyk and Michael Wink, Pretoria 2004, 199]
[Structural revision of pregnane ester glycosides from condurango cortex and new compounds., Berger, S., Junior, P., Kopanski, L., Phytochemistry, 27(5), 1988, 1451-1458]
„In traditional systems of medicine including homeopathy, the Condurango extract (Con) is often used to cure stomach cancer mainly, without having any scientific validation of its anti-cancer ability. Con has therefore been tested against non-small-cell lung cancer cells (NSCLC) A549 and NCI-H522 (H522) known to contain the KRAS mutation, making them resistant to most chemotherapeutic agents… overall results suggest considerable anticancer potential of Con against NSCLC in vitro, validating its use against lung cancer by practitioners of traditional medicine including homeopathy.“
[Ethanolic extract of Condurango (Marsdenia condurango) used in traditional systems of medicine including homeopathy against cancer can induce DNA damage and apoptosis in non small lung cancer cells, A549 and H522, in vitro., Sikdar, S., Mukherjee, A., Boujedaini, N., Khuda-Bukhsh, A. R., TANG, 3(1), 2013, 43-52]
„Chemotherapeutic potential of Condurango glycoside-rich components (CGS) was evaluated in NSCLC, in vitro and in BaP-intoxicated rats, in vivo… Overall results advocate considerable apoptosis-inducing potential of CGS against NSCLC, validating its use against lung cancer by CAM practitioners.“
[Condurango glycoside-rich components stimulate DNA damage-induced cell cycle arrest and ROS-mediated caspase-3 dependent apoptosis through inhibition of cell-proliferation in lung cancer,in vitro and in vivo., Sikdar, S., Mukherjee, A., Ghosh, S., Khuda-Bukhsh, A. R., Environmental toxicology and pharmacology, 37(1), 2014, 300-314]