Tinkturenpresse

Dies ist eine alte Version des Dokuments!

---

Cnidium officinale Makino - Apiaceae - chunkung, cheongung (kor.), senkyū (jap.)

Perennial herb native to Korea, China and Japan, extensively cultivated there.

„The [dried] rhizomes of C. officinale (Cinidii Rhizoma)… are used in the treatment of pain, inflammation, menstrual disturbance, and anti-vitamin deficiency disease, and also act as a blood pressure depressant. In addition, there are several reports suggesting that they have pharmacological properties to tumor metastasis and angiogenesis and that they act as an inhibitor of high glucose-induced proliferation of glomerular mesangial cells… C.officinale and L. chuanxiong are closely related species with 98% of sequence identity… C. officinale had the greatest activity to quench NO radical. The IC50 values were 57.25 and 76.50 µg/ml for C. officinale and L. chuanxiong, respectively. [control: ascrobic acid 9.88µg/ml]“
[Free radical scavenging activities of Cnidium officinale Makino and Ligusticum chuanxiong Hort. methanolic extracts., Ramalingam, M., Yong-Ki, P., Pharmacognosy magazine, Vol.6(24), 2010, 323]
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992148/

„The anti-inflammatory and anticancer activities of a methanol extract of the rhizome of Cnidium officinale were investigated. Four compounds, namely falcarindiol, 6-hydroxy-7-methoxy-dihydroligustilide, ligustilidiol, and senkyunolide H were isolated from the extract of the rhizome of Cnidium officinale and their structures were elucidated by analysis of their spectroscopic data and by comparison with previously reported data. These compounds showed anti-inflammatory activities, measured as inhibition of nitric oxide (NO) release in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells, with IC 50 values of 4.31 ± 5.22, 152.95 ± 4.23, 72.78 ± 5.13, and 173.42 ± 3.22 μM, respectively. They also inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA expression induced by LPS. Among these compounds, falcarindiol was found to have anti-proliferative effect against MCF-7 human breast cancer cells by induction of a G 0 /G 1 cell cycle block of the cells, with an IC 50 value of 35.67 μM.“
[Components of rhizome extract of Cnidium officinale Makino and their in vitro biological effects., Bae, K.E., Choi, Y.W., Kim, S.T., Kim, Y.K., Molecules, Vol.16(10), 2011, 8833-8847]
http://mdpi.com/1420-3049/16/10/8833/pdf