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Angelica dahurica (Fischer ex Hoffmann) Bentham & J. D. Hooker ex Franchet & Savatier - Apiaceae
白芷 bai zhi (chin.)
Stout perennial 1–2.5m high, native to China, Japan, Korea, Siberia; root strongly aromatic; stem purplish green; flowers white.
var. dahurica: Ovary and fruit glabrous (NE China)
var. formosana: Ovary and fruit pubescent (Taiwan).
„ This species is widely cultivated in N China, where the roots are used as the important traditional Chinese medicine “bai zhi” and as a substitute, known as “dong bei da huo,” for the traditional Chinese medicine “du huo” (see Angelica biserrata). Two cultivars are common: A. dahurica ‘Hangbaizhi’ and A. dahurica ‘Qibaizhi.’ “
http://www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=200015358
„Angelica dahurica… root has been most frequently prescribed as a sedative and an analgesic in Chinese medicine.
The 80% aqueous MeOH extracts from the root of Angelica dahurica, found to inhibit the activities of GABA
degradative enzymes GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH),
were fractionated using EtOAc, n-BuOH and H2O. Repeated column chromatography for the EtOAc and
n-BuOH fractions led to the isolation of two new coumarins, oxypeucedanin hydrate-3′′′′-butyl ether and
isopraeroside IV along with six known coumarins, isoimperatorin, imperatorin, phellopterin, oxypeucedanin
hydrate, nodakenin and 3′′-hydroxymarmesinin, and two polyacetylenes, falcarindiol and octadeca-1,9-dien-
4,6-diyn-3,8,18-triol. Of the isolated pure compounds, imperatorin and falcarindiol inactivated the GABA-T
activities in both time- and concentration-dependent manners. The kinetic studies showed that imperatorin
and falcarindiol reacted with the GABA-T with a second-order rate constant of 2.3 ± 0.2 mM−1 min−1 and
1.5 ± 0.1 mM−1 min−1, respectively. It is postulated that imperatorin and falcarindiol are able to elevate the
neurotransmitter GABA levels in the central nervous system by an inhibitory action on the GABA degradative
enzyme GABA-T.“
[In vitro GABA‐transaminase inhibitory compounds from the root of Angelica dahurica. Choi, S. Y., Ahn, E. M., Song, M. C., Kim, D. W., Kang, J. H., Kwon, O. S., Baek, N. I., Phytotherapy Research, Vol.19(10), 2005, 839-845]
From „the dried mature fruits of A.dahurica, which is one of the most popular traditional Chinese herbal medicines (TCHMs) to treat frontal headache, toothache, rhinitis, boils, carbuncles and skin diseases“, 23 furocoumarins were idientified.
http://onlinelibrary.wiley.com/doi/10.1002/rcm.4123/full