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commiphora_myrrha_nees_engl [2018/07/24 15:01]
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commiphora_myrrha_nees_engl [2022/09/02 14:17] (aktuell)
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| | {{:furano1.jpg|furanoeudesma-1,3-diene}} \\ furanoeudesma-1,3-diene | {{:lindestrene.jpg|lindestrene}} \\ lindestrene | {{:dihydropyrocurzerenone.jpg|dihydropyrocurzerenone}} \\ dihydropyrocurzerenone | | | {{:furano1.jpg|furanoeudesma-1,3-diene}} \\ furanoeudesma-1,3-diene | {{:lindestrene.jpg|lindestrene}} \\ lindestrene | {{:dihydropyrocurzerenone.jpg|dihydropyrocurzerenone}} \\ dihydropyrocurzerenone | |
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| | From the hexan extract of myrh resin from C.molmol, 8 sesquiterpene fractions were isolated, with furanodiene, furanoeudesma-1,3-diene and curzerene, methoxyfuranodiene, acetoxyfuranodiene, curzerenone, furanodiene-6-one and methoxyfuranoguaia-9-ene-8-one, furanogermacrene-3, furanogermacrene-1 and fraction 8, furanogermacrene-2. The mixture of furanodiene-6-one and methoxyfuranoguaia-9-ene-8-one showed antibacterial and antifungal activity against standard pathogenic strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans, with minimum inhibitory concentrations ranging from 0.18 to 2.8 μg/ml. These compounds also had local anaesthetic activity, blocking the inward sodium current of excitable mammalian membranes. \\ |
| | [Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes from myrrh. Dolara, P., Corte, B., Ghelardini, C., Pugliese, A. M., Cerbai, E., Menichetti, S., Nostro, A. L., Planta medica, Vol.66(04), 2000, 356-358] |
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| The essential oil obtained from the oleo-gum resin of C.myrrha by hydrodistillation (3.1%) was examined by using GC and GC/MS. "Among the 32 components identified in this oil, [[http://www.pherobase.com/database/kovats/kovats-detail-curzerene.php|curzerene]] (40.1%), furanoeudesma-1,3-diene (15.0%), β-elemene (8.4%) and 2-O-acetyl-8,12-epoxygermacra-1(10),4,7,11-tetraene, isomer I (6.5%) were found to be the major constituents." \\ | The essential oil obtained from the oleo-gum resin of C.myrrha by hydrodistillation (3.1%) was examined by using GC and GC/MS. "Among the 32 components identified in this oil, [[http://www.pherobase.com/database/kovats/kovats-detail-curzerene.php|curzerene]] (40.1%), furanoeudesma-1,3-diene (15.0%), β-elemene (8.4%) and 2-O-acetyl-8,12-epoxygermacra-1(10),4,7,11-tetraene, isomer I (6.5%) were found to be the major constituents." \\ |
| "Furanoeudesma-1,3-diene possesses a sweet, warm, leathery-balsamic odor similar to that of lindestrene, while dihydropyrocurzerenone elicits a rich resinous odor impression." \\ | "Furanoeudesma-1,3-diene possesses a sweet, warm, leathery-balsamic odor similar to that of lindestrene, while dihydropyrocurzerenone elicits a rich resinous odor impression." \\ |
| [Scent and Chemistry, Günther Ohloff, Wilhelm Pickenhagen, Philip Kraft, Wiley-VCH, 2012, 325] | [Scent and Chemistry, Günther Ohloff, Wilhelm Pickenhagen, Philip Kraft, Wiley-VCH, 2012, 325] |
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| From the hexan extract of myrh resin from C.molmol, 8 sesquiterpene fractions were isolated, with furanodiene, furaneudesma-1,3-diene and curzerene, methoxyfuranodiene, acetoxyfuranodiene, curzerenone, furanodiene-6-one and methoxyfuranoguaia-9-ene-8-one, furanogermacrene-3, furanogermacrene-1 and fraction 8, furanogermacrene-2. The mixture of furanodiene-6-one and methoxyfuranoguaia-9-ene-8-one showed antibacterial and antifungal activity against standard pathogenic strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans, with minimum inhibitory concentrations ranging from 0.18 to 2.8 μg/ml. These compounds also had local anaesthetic activity, blocking the inward sodium current of excitable mammalian membranes. \\ | |
| [Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes from myrrh. Dolara, P., Corte, B., Ghelardini, C., Pugliese, A. M., Cerbai, E., Menichetti, S., Nostro, A. L., Planta medica, Vol.66(04), 2000, 356-358] | |
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| To prepare pharmaceutical formulations of mouthwashes, containing extracted Yemeni myrrh as a single active constituent, different solvents were used to prepare myrrh extract. An hydroalcohol extract of myrrh with ethanol: phosphate buffer pH 7 (85:15) showed the best antimicrobial activity against Staphylococcus aureus. The selected myrrh mouthwash formulations revealed remarkable antimicrobial activity against Staph. aureus and Strep. mutans, greater than all other tested products with chlorhexidine gluconate or benzydamine HCl. \\ | To prepare pharmaceutical formulations of mouthwashes, containing extracted Yemeni myrrh as a single active constituent, different solvents were used to prepare myrrh extract. An hydroalcohol extract of myrrh with ethanol: phosphate buffer pH 7 (85:15) showed the best antimicrobial activity against Staphylococcus aureus. The selected myrrh mouthwash formulations revealed remarkable antimicrobial activity against Staph. aureus and Strep. mutans, greater than all other tested products with chlorhexidine gluconate or benzydamine HCl. \\ |
| [Antimicrobial activity of Yemeni myrrh mouthwash. Almekhlafi, S., Thabit, A. A., Alwossabi, A. M., Awadth, N., Thabet, A. A., Algaadari, Z., Journal of Chemical and Pharmaceutical Research, Vol.6(5), 2014, 1006-1013] [[http://jocpr.com/vol6-iss5-2014/JCPR-2014-6-5-1006-1013.pdf]] | [Antimicrobial activity of Yemeni myrrh mouthwash. Almekhlafi, S., Thabit, A. A., Alwossabi, A. M., Awadth, N., Thabet, A. A., Algaadari, Z., Journal of Chemical and Pharmaceutical Research, Vol.6(5), 2014, 1006-1013] [[http://jocpr.com/vol6-iss5-2014/JCPR-2014-6-5-1006-1013.pdf]] |
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| | Main components of the Commiphora myrrha oleogum resin essential oil were δ-elemene (2.0%), β-elemene (9.1%), γ-elemene (2.7%), germacrene D (3.3%), curzerene (29.7%), germacrene B (4.6%), furanoeudesma-1,3-diene (17.4%), and lindestrene (8.7%). \\ |
| | [Ulrich, Judith, et al. "Phytochemical Composition of Commiphora Oleogum Resins and Their Cytotoxicity against Skin Cancer Cells." Molecules 27.12 (2022): 3903] [[https://www.mdpi.com/1420-3049/27/12/3903/pdf?version=1655476710|PDF (mdpi.com)]] |
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| {{:commiphora_molmol.jpg?600}} \\ | {{:commiphora_molmol.jpg?600}} \\ |
| Köhler,F.E., Medizinal Pflanzen, vol.2 t.185 (1890) \\ | Köhler,F.E., Medizinal Pflanzen, vol.2 t.185 (1890) \\ |
| [[http://plantgenera.org/species.php?id_species=267761]] | [[http://plantgenera.org/species.php?id_species=267761]] |
