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--- sanguinaria_canadensis_l [2015/10/25 08:10] – andreas
+++ sanguinaria_canadensis_l [2015/10/25 08:12] (aktuell) – andreas
@@ Zeile 23: / Zeile 23: @@
 Sanguinarine has recently been shown to exhibit potent anti-MRSA activity in vitro by disrupting the cytoplasmic membrane of MRSA. "The activity of sanguinarine against MRSA strains ranged from 3.12 to 6.25 µg/ml, while the minimum inhibitory concentrations of the two reference strains are 3.12 µg/ml and 1.56 µg/ml. The treatment of the cells with sanguinarine induced the release of membrane-bound cell wall autolytic enzymes, which eventually resulted in lysis of the cell." \\
 [The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus., Obiang-Obounou, B.W., Kang, O.H., Choi, J.G., Keum, J.H., Kim, S.B., Mun, S.H., Kwon, D.Y. The Journal of toxicological sciences, 36(3), 2011, 277-283]
+"The first crystal structures of Berberine and Sanguinarine intercalated with a d(CGTACG)2 DNA sequence were obtained by X-ray diffraction analysis at 2.3 Å resolution. Both drugs join the end of two “two-molecules” DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)2 DNA in its iminium form." \\
+[X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d (CGTACG)., Ferraroni, M., Bazzicalupi, C., Bilia, A.R., Gratteri, P., Chemical Communications, 47(17), 2011, 4917-4919]
 {{:sanguinaria_canadensis.jpg?500}} \\
 Millspaugh,C.F., American medicinal plants, vol.1, t.22 (1892) \\
 [[http://plantgenera.org/species.php?id_species=904722]]