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paris_quadrifolia_l [2016/02/21 16:38] andreasparis_quadrifolia_l [2016/02/21 16:43] (aktuell) andreas
Zeile 15: Zeile 15:
 Pennogenyl saponins pennogenin 3-O-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside and pennogenin 3-O-α-L-rhamnopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside exhibited strong cytotoxic activity against HL-60, HeLa and MCF-7 tumour cells. \\ Pennogenyl saponins pennogenin 3-O-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside and pennogenin 3-O-α-L-rhamnopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside exhibited strong cytotoxic activity against HL-60, HeLa and MCF-7 tumour cells. \\
 [Isolation and identification of cytotoxic compounds from the rhizomes of Paris quadrifolia L., Gajdus, J., Kaczyński, Z., Kawiak, A., Łojkowska, E., Stefanowicz-Hajduk, J., Ochocka, J.R., Stepnowski, P., Pharmacognosy magazine, 10(Suppl 2), 2014, S324] [Isolation and identification of cytotoxic compounds from the rhizomes of Paris quadrifolia L., Gajdus, J., Kaczyński, Z., Kawiak, A., Łojkowska, E., Stefanowicz-Hajduk, J., Ochocka, J.R., Stepnowski, P., Pharmacognosy magazine, 10(Suppl 2), 2014, S324]
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 +Regarding the the molecular mechanisms of cytotoxic effects of pennogenyl saponins, both the extrinsic death receptor and intrinsic mitochondrial pathways are involved in the programmed cell death. \\
 +[Pennogenyl Saponins from Paris quadrifolia L. Induce Extrinsic and Intrinsic Pathway of Apoptosis in Human Cervical Cancer HeLa Cells., Stefanowicz-Hajduk, J., Bartoszewski, R., Bartoszewska, S., Kochan, K., Adamska, A., Kosiński, I., Ochocka, J.R., PloS one, 10(8), 2015, e0135993] [[http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135993]]
  
 {{:paris_quadrifolia.jpg?500|}} \\ {{:paris_quadrifolia.jpg?500|}} \\
 Redouté, P.J., Les Liliacées, vol.4 t.226 (1805-1816) \\ Redouté, P.J., Les Liliacées, vol.4 t.226 (1805-1816) \\
 [[http://plantgenera.org/species.php?id_species=749983]] [[http://plantgenera.org/species.php?id_species=749983]]
paris_quadrifolia_l.1456072683.txt.gz · Zuletzt geändert: 2016/02/21 16:38 von andreas

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