| Beide Seiten der vorigen RevisionVorhergehende ÜberarbeitungNächste Überarbeitung | Vorhergehende Überarbeitung |
| cucurbita_pepo_l [2016/01/17 18:42] – andreas | cucurbita_pepo_l [2016/10/02 06:45] (aktuell) – andreas |
|---|
| |
| The seeds of C.pepo subsp.pepo (especially var.styriaca and var.oleifera; pumpkin seed, Cucurbitae semen, Kürbissamen) and preparations thereof are used to treat benign prostatic hyperplasia (BPH) related lower urinary tract symptoms (LUTS). Treated symptoms include urinary retention, frequent urination, nocturia, incomplete emptying, intermittency, urgency, weakness of the urinary system and also overactive bladder syndrome. \\ | The seeds of C.pepo subsp.pepo (especially var.styriaca and var.oleifera; pumpkin seed, Cucurbitae semen, Kürbissamen) and preparations thereof are used to treat benign prostatic hyperplasia (BPH) related lower urinary tract symptoms (LUTS). Treated symptoms include urinary retention, frequent urination, nocturia, incomplete emptying, intermittency, urgency, weakness of the urinary system and also overactive bladder syndrome. \\ |
| The seeds contain Δ-7 sterols and their glucosides which are thought to be the active compounds - by inhibition of dihydrotestosterone binding to cytoplasmic receptors. \\ | The seeds contain Δ-7 sterols (also Δ-5 an Δ-8 sterols, together about 1%) and their glucosides which are thought to be the active compounds - by inhibition of dihydrotestosterone binding to cytoplasmic receptors. \\ |
| [Teedrogen, Max Wichtl, 2016, 207-209] | [Wolfgang Blaschek ed., Wichtl - Teedrogen und Phytopharmaka: Ein Handbuch für die Praxis, 2015, 207-209] |
| |
| {{:delta7sterols.jpg|}} \\ | {{:delta7sterols.jpg|}} \\ |
| Δ-7 sterols: 24β-ethyl-5α-cholesta-7,25-diene-3β-ol and 24β-ethyl-5α-cholesta-7,22,25-triene-3β-ol | Δ-7 sterols: 24β-ethyl-5α-cholesta-7,25-diene-3β-ol and 24β-ethyl-5α-cholesta-7,22,25-triene-3β-ol (double bond C-22) |
| |
| "The German Research Activities on Natural Urologicals (GRANU) study was a randomized, partially blinded, placebo-controlled, parallel-group trial that investigated the efficacy of pumpkin seed in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS)... A total of 1,431 men (50−80 years) with BPH/LUTS were randomly assigned to either pumpkin seed (5 g b.i.d.), capsules with pumpkin seed extract (500 mg b.i.d.) or matching placebo. The primary response criterion was a decrease in International Prostate Symptom Score (IPSS) of ≥5 points from baseline after 12 months... After 12 months, the response rate (intention-to-treat/last-observation-carried-forward approach) did not differ between pumpkin seed extract and placebo. In the case of pumpkin seed (responders: 58.5%), the difference compared with placebo (responders: 47.3%) was descriptively significant. The study products were well tolerated. Overall, in men with BPH, 12 months of treatment with pumpkin seed led to a clinically relevant reduction in IPSS compared with placebo." \\ | "The German Research Activities on Natural Urologicals (GRANU) study was a randomized, partially blinded, placebo-controlled, parallel-group trial that investigated the efficacy of pumpkin seed in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS)... A total of 1,431 men (50−80 years) with BPH/LUTS were randomly assigned to either pumpkin seed (5 g b.i.d.), capsules with pumpkin seed extract (500 mg b.i.d.) or matching placebo. The primary response criterion was a decrease in International Prostate Symptom Score (IPSS) of ≥5 points from baseline after 12 months... After 12 months, the response rate (intention-to-treat/last-observation-carried-forward approach) did not differ between pumpkin seed extract and placebo. In the case of pumpkin seed (responders: 58.5%), the difference compared with placebo (responders: 47.3%) was descriptively significant. The study products were well tolerated. Overall, in men with BPH, 12 months of treatment with pumpkin seed led to a clinically relevant reduction in IPSS compared with placebo." \\ |
