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xanthium_strumarium_l [2015/12/28 19:28] andreas |
xanthium_strumarium_l [2015/12/28 19:29] (aktuell) andreas |
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The plant contains carboxyatractyloside (CATR), which leads to an infrequent but often fatal form of herbal poisoning. "Both ATR and CATR inhibit the transport of ADP across the mitochondrial membrane, preventing the synthesis of ATP and leading to failure in gluconeogenesis and cell death because of energy starvation... Poisoning in humans may present with either acute hepatic or renal pathology and it is possible that there is a second, different mechanism of toxicity to the hepatocyte. Atractyloside in large amounts gives rise to massive necrosis, but in vitro studies have shown that at lower doses cells progress to apoptosis." | The plant contains carboxyatractyloside (CATR), which leads to an infrequent but often fatal form of herbal poisoning. "Both ATR and CATR inhibit the transport of ADP across the mitochondrial membrane, preventing the synthesis of ATP and leading to failure in gluconeogenesis and cell death because of energy starvation... Poisoning in humans may present with either acute hepatic or renal pathology and it is possible that there is a second, different mechanism of toxicity to the hepatocyte. Atractyloside in large amounts gives rise to massive necrosis, but in vitro studies have shown that at lower doses cells progress to apoptosis." | ||
- | [The biochemistry and toxicity of atractyloside: | + | [The biochemistry and toxicity of atractyloside: |
The methanol extract of the semen of Xanthium strumarium L. (MEXS) acts as a potent inhibitor of NO, PGE2 and TNF-α production. " | The methanol extract of the semen of Xanthium strumarium L. (MEXS) acts as a potent inhibitor of NO, PGE2 and TNF-α production. " |