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valeriana_officinalis_l [2022/06/19 08:52] andreas |
valeriana_officinalis_l [2022/10/24 14:46] (aktuell) andreas |
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- | "A comprehensive search of studies investigating valerian was conducted through computerized databases and hand | + | "The data suggest that activation of adenosine A1 and GABA A receptors is mediated by different components within the valerian extract. The two mechanisms may contribute independently to the sleep-inducing effect of valerian." |
- | searches of reference lists. Standardized forms were used to summarize findings and standardized criteria were used to assess study quality. Out of 592 articles initially identified, a total of 36 articles describing 37 separate studies met criteria for review: 29 controlled trials evaluated for both efficacy and safety, and eight open-label trials evaluated for safety only. Most studies found no significant differences between valerian and placebo either in healthy individuals or in persons with general sleep disturbance or insomnia. None of the most recent studies, which were also the most methodologically rigorous, found significant effects of valerian on sleep. Overall, the evidence, while supporting that valerian is a safe herb associated with | + | [Sichardt, K., et al. " |
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+ | "A comprehensive search of studies investigating valerian was conducted through computerized databases and hand searches of reference lists. Standardized forms were used to summarize findings and standardized criteria were used to assess study quality. Out of 592 articles initially identified, a total of 36 articles describing 37 separate studies met criteria for review: 29 controlled trials evaluated for both efficacy and safety, and eight open-label trials evaluated for safety only. Most studies found no significant differences between valerian and placebo either in healthy individuals or in persons with general sleep disturbance or insomnia. None of the most recent studies, which were also the most methodologically rigorous, found significant effects of valerian on sleep. Overall, the evidence, while supporting that valerian is a safe herb associated with | ||
only rare adverse events, does not support the clinical efficacy of valerian as a sleep aid for insomnia" | only rare adverse events, does not support the clinical efficacy of valerian as a sleep aid for insomnia" | ||
[A systematic review of valerian as a sleep aid: safe but not effective. Taibi, D. M., Landis, C. A., Petry, H., Vitiello, M. V. , Sleep medicine reviews, Vol.11(3), 2007, 209-230] \\ | [A systematic review of valerian as a sleep aid: safe but not effective. Taibi, D. M., Landis, C. A., Petry, H., Vitiello, M. V. , Sleep medicine reviews, Vol.11(3), 2007, 209-230] \\ |