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Tetradium ruticarpum (A. Juss.) T. G. Hartley - syn.Euodia officinalis Dode; Euodia ruticarpa (A. Juss.) Benth.; Boymia ruticarpa A. Juss. - Rutaceae - 吴茱萸 wu zhu yu (chin.), evodia

Shrub or tree, to 9m tall, native to China and Korea.
http://www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=242351597

„The fruit is usually used. It has a strong bitter taste, and is used in traditional Chinese medicine (TCM). Both the former genus name and the species name are often misspelled, and the plant usually appears in sources dealing with traditional Chinese medicine as „Evodia rutaecarpa“.“
http://en.wikipedia.org/wiki/Tetradium_ruticarpum

Limonin, the bitter principle from the dried fruits of Evodia rutaecarpa, showed inhibitory effects on bradykinin-induced paw edema and arachidonic acid-induced ear swelling. „Limonin inhibited the rise of vascular permeability induced by acetic acid and the increase of paw edema induced by carrageenin.“
[Antinociceptive and anti-inflammatory activities of limonin isolated from the fruits of Evodia rutaecarpa var. bodinieri., Matsuda, H., Yoshikawa, M., Iinuma, M., Kubo, M., Planta medica, Vol.64(4), 1998, 339-342]

„Wuzhuyu has been used in TCM for the treatment of inflammation-related disorders such as gastrointestinal problems, headache, menstrual complaints and externally against mouth ulcers…he n-hexane extract of the fruits of Evodia rutaecarpa showed a considerable inhibiting effect on leukotriene biosynthesis in hu- man granulocytes. Bioassay-guided fractionation of the extract led to the isolation of the 5 quinolone alkaloids: 1-methyl-2-nonyl-4(1H)-quinolinone, 1-methyl-2-(6Z)-6-undecenyl-4(1H)-quinolinone, 1-methyl-2-(4Z,7Z)-4,7-tridecadienyl-4(1H)-quinolinone, evocarpine and 1-methyl-2-(6Z,9Z)-6,9-pentadecadienyl-4(1H)-quinolinone. The compounds exhibited inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1, 10.0, 10.1, 14,6 and 12.3 mM, respectively.“
[Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa., Adams, M., Kunert, O., Haslinger, E., Bauer, R., Planta medica, Vol.70, 2004, 904-908]

„Wu-Zhu-Yu, is an extract prepared from the small berry fruit of Evodia rutaecarpa and is reported to have anti-inflammatory and anti-nociceptic activity… In order to control the potency of the test article, we prepared a defined biomimetic mixture of synthetic and natural forms of the active components of Evodia fruit extract, containing rutaecarpine, dehydroevodiamine, and evodin… This Evodia biomimetic mixture was a potent inhibitor of UVB-induced PGE2 released by keratinocytes in culture. We found that MN also induces release of nitric oxide from cultured keratinocytes and microvascular endothelial cells. Twice daily application of 0.1–1% Evodia biomimetic mixture for 2 weeks significantly inhibited erythema after a MN challenge. A single application of 1% Evodia biomimetic mixture also significantly inhibited MN-induced erythema when applied at 60 min before, or within 5 min after MN exposure. The Evodia biomimetic mixture was significantly more effective at inhibiting erythema than bisabolol, the active component of chamomile. Conclusions: These results demonstrate that compounds found in E. rutaecarpa (including the indole quinazoline alkaloids) have powerful anti-inflammatory activity when applied topically to human skin.“
[Anti-inflammatory activity in skin by biomimetic of Evodia rutaecarpa extract from traditional Chinese medicine., Yarosh, D.B., Galvin, J.W., Nay, S.L., Peña, A.V., Canning, M.T., Brown, D.A., Journal of dermatological science, Vol.42(1), 2006, 13-21]

Euodia ruticarpa (A. Juss.) Benth. [as Boymia ruticarpa A. Juss.]
Siebold, P.F. von, Zuccarini, J.G., Flora Japonica, t. 21 (1875)
http://plantgenera.org/species.php?id_species=416734