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sanguinaria_canadensis_l [2015/10/25 09:10] andreas |
sanguinaria_canadensis_l [2015/10/25 09:12] (aktuell) andreas |
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Sanguinarine has recently been shown to exhibit potent anti-MRSA activity in vitro by disrupting the cytoplasmic membrane of MRSA. "The activity of sanguinarine against MRSA strains ranged from 3.12 to 6.25 µg/ml, while the minimum inhibitory concentrations of the two reference strains are 3.12 µg/ml and 1.56 µg/ml. The treatment of the cells with sanguinarine induced the release of membrane-bound cell wall autolytic enzymes, which eventually resulted in lysis of the cell." \\ | Sanguinarine has recently been shown to exhibit potent anti-MRSA activity in vitro by disrupting the cytoplasmic membrane of MRSA. "The activity of sanguinarine against MRSA strains ranged from 3.12 to 6.25 µg/ml, while the minimum inhibitory concentrations of the two reference strains are 3.12 µg/ml and 1.56 µg/ml. The treatment of the cells with sanguinarine induced the release of membrane-bound cell wall autolytic enzymes, which eventually resulted in lysis of the cell." \\ | ||
[The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus., Obiang-Obounou, | [The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus., Obiang-Obounou, | ||
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+ | "The first crystal structures of Berberine and Sanguinarine intercalated with a d(CGTACG)2 DNA sequence were obtained by X-ray diffraction analysis at 2.3 Å resolution. Both drugs join the end of two “two-molecules” DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)2 DNA in its iminium form." \\ | ||
+ | [X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d (CGTACG)., Ferraroni, M., Bazzicalupi, | ||
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Millspaugh, | Millspaugh, | ||
[[http:// | [[http:// |