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Nächste Überarbeitung 		Vorhergehende Überarbeitung
sanguinaria_canadensis_l [2015/10/23 20:27]
andreas 		sanguinaria_canadensis_l [2015/10/25 09:12] (aktuell)
andreas
Zeile 11: Zeile 11:
 "A sanguinaria-containing toothpaste and oral rinse regimen was evaluated during a 6-month period to determine its effectiveness in controlling plaque, gingival inflammation, and sulcular bleeding... The sanguinaria regimen reduced plaque by 57%, gingival inflammation by 60%, and sulcular bleeding by 45% from baseline compared with placebo group reductions of 27% (plaque) and 21% (gingival inflammation), and an increase of 30% in bleeding index...  the combined use of the sanguinaria-containing toothpaste and oral rinse controls and reduces plaque and gingival inflammation in an orthodontic population." \\ "A sanguinaria-containing toothpaste and oral rinse regimen was evaluated during a 6-month period to determine its effectiveness in controlling plaque, gingival inflammation, and sulcular bleeding... The sanguinaria regimen reduced plaque by 57%, gingival inflammation by 60%, and sulcular bleeding by 45% from baseline compared with placebo group reductions of 27% (plaque) and 21% (gingival inflammation), and an increase of 30% in bleeding index...  the combined use of the sanguinaria-containing toothpaste and oral rinse controls and reduces plaque and gingival inflammation in an orthodontic population." \\
 [Long-term clinical evaluation of toothpaste and oral rinse containing sanguinaria extract in controlling plaque, gingival inflammation, and sulcular bleeding during orthodontic treatment., Hannah, J.J., Johnson, J.D., Kuftinec, M.M., American Journal of Orthodontics and Dentofacial Orthopedics, 96(3), 1989, 199-207] [Long-term clinical evaluation of toothpaste and oral rinse containing sanguinaria extract in controlling plaque, gingival inflammation, and sulcular bleeding during orthodontic treatment., Hannah, J.J., Johnson, J.D., Kuftinec, M.M., American Journal of Orthodontics and Dentofacial Orthopedics, 96(3), 1989, 199-207]
 +
 +"... berberine and sanguinarine intercalate DNA, inhibit DNA synthesis and reverse transcriptase. In addition, sanguinarine (but not berberine) affects membrane permeability and berberine protein biosynthesis. In consequence, these biochemical activities may mediate chemical defence against microorganisms, viruses and herbivores in the plants producing these alkaloids." \\
 +[Biochemical activities of berberine, palmatine and sanguinarine mediating chemical defence against microorganisms and herbivores., Schmeller, T., Latz-Brüning, B., Wink, M., Phytochemistry, 44(2), 1997, 257-266]
  
 "The rhizome extracts, as well as a methanol extract of S. canadensis suspension-cell cultures inhibited the growth of H. pylori in vitro, with a MIC50 range of 12.5–50.0 µg/ml. Three isoquinoline alkaloids were identified in the active fraction. Sanguinarine and chelerythrine, two benzophenanthridine alkaloids, inhibited the growth of the bacterium, with an MIC50 of 50.0 and 100.0 µg/ml, respectively." \\ "The rhizome extracts, as well as a methanol extract of S. canadensis suspension-cell cultures inhibited the growth of H. pylori in vitro, with a MIC50 range of 12.5–50.0 µg/ml. Three isoquinoline alkaloids were identified in the active fraction. Sanguinarine and chelerythrine, two benzophenanthridine alkaloids, inhibited the growth of the bacterium, with an MIC50 of 50.0 and 100.0 µg/ml, respectively." \\
Zeile 20: Zeile 23:
 Sanguinarine has recently been shown to exhibit potent anti-MRSA activity in vitro by disrupting the cytoplasmic membrane of MRSA. "The activity of sanguinarine against MRSA strains ranged from 3.12 to 6.25 µg/ml, while the minimum inhibitory concentrations of the two reference strains are 3.12 µg/ml and 1.56 µg/ml. The treatment of the cells with sanguinarine induced the release of membrane-bound cell wall autolytic enzymes, which eventually resulted in lysis of the cell." \\ Sanguinarine has recently been shown to exhibit potent anti-MRSA activity in vitro by disrupting the cytoplasmic membrane of MRSA. "The activity of sanguinarine against MRSA strains ranged from 3.12 to 6.25 µg/ml, while the minimum inhibitory concentrations of the two reference strains are 3.12 µg/ml and 1.56 µg/ml. The treatment of the cells with sanguinarine induced the release of membrane-bound cell wall autolytic enzymes, which eventually resulted in lysis of the cell." \\
 [The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus., Obiang-Obounou, B.W., Kang, O.H., Choi, J.G., Keum, J.H., Kim, S.B., Mun, S.H., Kwon, D.Y. The Journal of toxicological sciences, 36(3), 2011, 277-283] [The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus., Obiang-Obounou, B.W., Kang, O.H., Choi, J.G., Keum, J.H., Kim, S.B., Mun, S.H., Kwon, D.Y. The Journal of toxicological sciences, 36(3), 2011, 277-283]
 +
 +"The first crystal structures of Berberine and Sanguinarine intercalated with a d(CGTACG)2 DNA sequence were obtained by X-ray diffraction analysis at 2.3 Å resolution. Both drugs join the end of two “two-molecules” DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)2 DNA in its iminium form." \\
 +[X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d (CGTACG)., Ferraroni, M., Bazzicalupi, C., Bilia, A.R., Gratteri, P., Chemical Communications, 47(17), 2011, 4917-4919]
  
 {{:sanguinaria_canadensis.jpg?500}} \\ {{:sanguinaria_canadensis.jpg?500}} \\
 Millspaugh,C.F., American medicinal plants, vol.1, t.22 (1892) \\ Millspaugh,C.F., American medicinal plants, vol.1, t.22 (1892) \\
 [[http://plantgenera.org/species.php?id_species=904722]] [[http://plantgenera.org/species.php?id_species=904722]]
sanguinaria_canadensis_l.1445624848.txt.gz · Zuletzt geändert: 2015/10/23 20:27 von andreas

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