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sanguinaria_canadensis_l [2015/10/23 15:50] andreas |
sanguinaria_canadensis_l [2015/10/25 09:12] (aktuell) andreas |
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"In isolated, isometrically contracting left guinea pig atria, sanguinarine, | "In isolated, isometrically contracting left guinea pig atria, sanguinarine, | ||
[Sanguinarine: | [Sanguinarine: | ||
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+ | "A sanguinaria-containing toothpaste and oral rinse regimen was evaluated during a 6-month period to determine its effectiveness in controlling plaque, gingival inflammation, | ||
+ | [Long-term clinical evaluation of toothpaste and oral rinse containing sanguinaria extract in controlling plaque, gingival inflammation, | ||
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+ | "... berberine and sanguinarine intercalate DNA, inhibit DNA synthesis and reverse transcriptase. In addition, sanguinarine (but not berberine) affects membrane permeability and berberine protein biosynthesis. In consequence, | ||
+ | [Biochemical activities of berberine, palmatine and sanguinarine mediating chemical defence against microorganisms and herbivores., | ||
"The rhizome extracts, as well as a methanol extract of S. canadensis suspension-cell cultures inhibited the growth of H. pylori in vitro, with a MIC50 range of 12.5–50.0 µg/ml. Three isoquinoline alkaloids were identified in the active fraction. Sanguinarine and chelerythrine, | "The rhizome extracts, as well as a methanol extract of S. canadensis suspension-cell cultures inhibited the growth of H. pylori in vitro, with a MIC50 range of 12.5–50.0 µg/ml. Three isoquinoline alkaloids were identified in the active fraction. Sanguinarine and chelerythrine, | ||
- | [In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis., | + | [In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis., |
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+ | The dried rhizome, with roots removed (Sanguinariae canadensis rhizoma), is traditionally used (infusion) as an emetic, expectorant and spasmolytic to treat bronchitis, asthma, cough, croup, laryngitis and pharyngitis. Most common modern use is (as extract in mouth rinses and toothpaste) to conteract dental plaque and gingivitis. "Since sanguinarin and some of the other alkaloids can intercalate DNA, they are potential mutagens. There is new evidence that prolonged use in oral hygiene products may be harmful." | ||
+ | [Medicinal Plants of the World. Ben-Erik Van Wyk and Michael Wink, Pretoria 2004, 286] | ||
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+ | Sanguinarine has recently been shown to exhibit potent anti-MRSA activity in vitro by disrupting the cytoplasmic membrane of MRSA. "The activity of sanguinarine against MRSA strains ranged from 3.12 to 6.25 µg/ml, while the minimum inhibitory concentrations of the two reference strains are 3.12 µg/ml and 1.56 µg/ml. The treatment of the cells with sanguinarine induced the release of membrane-bound cell wall autolytic enzymes, which eventually resulted in lysis of the cell." \\ | ||
+ | [The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus., Obiang-Obounou, | ||
+ | "The first crystal structures of Berberine and Sanguinarine intercalated with a d(CGTACG)2 DNA sequence were obtained by X-ray diffraction analysis at 2.3 Å resolution. Both drugs join the end of two “two-molecules” DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)2 DNA in its iminium form." \\ | ||
+ | [X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d (CGTACG)., Ferraroni, M., Bazzicalupi, | ||
{{: | {{: | ||
Millspaugh, | Millspaugh, | ||
[[http:// | [[http:// |