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Salvia sclarea L. - Lamiaceae
clary sage, clary, muscatel sage, Muskateller-Salbei

Biennial or perennial herb, 0.50-1.10m high, native from South Europe to Central Asia; leaves simple, up to 30cm long, heart-shaped; flowers white to mauve or violet.

„… the essential oil of S. sclarea L. is dominated by two monoterpenes, linalool and linalylacetate, which mostly determine the oil quality in all the tested phases of development; they constitute 86.07% from total oil mass.“
[Investigation on the essential oil of cultivated Salvia sclarea L., Pešić, P. Ž., & Banković, V. M., Flavour and fragrance journal, Vol.18(3), 2003, 228-230]

„The peculiar and highly diffusive odor signal of flowering clary-sage plants (Salvia sclarea L.) was identified to derive from trace amounts of 1-methoxyhexane-3-thiol (1) by mass-spectrometry analysis and confirmed by comparison with synthetic racemic thiol (±)-1. The enantiomers (S)- and (R)-1 were prepared by enantioselective synthesis, and the absolute configuration of (S)-1 was fully corroborated by X-ray-diffraction analysis of the crystalline thioester (1′S,1S)-2. Compound (S)-1 is one of the most powerful odorants known, with a detection threshold of 0.04⋅10−3 ng/l air, and is, with its herbaceous-green, alliaceous, and perspiration profile, key to the fragrance of clary-sage flowers and of the freshly distilled essential oil. As a consequence of its unique odor, 1 was also suspected to be part of the volatiles of a Ruta species where it was subsequently identified together with its homologue, 1-methoxyheptane-3-thiol (3), 1-methoxy-4-methylpentane-3-thiol (4), and the known 4-methoxy-2-methylbutane-2-thiol (5). The syntheses of (±)-3 and (±)-4 as well as of the enantiomer (R)-4 are described. In both natural fractions, the ratio (S)-1/(R)-1 was slightly in favor of the (S)-enantiomer. Natural 4 has (R)-configuration.“
[1‐Methoxyhexane‐3‐thiol, a Powerful Odorant of Clary Sage (Salvia sclarea L.). van de Waal, M., Niclass, Y., Snowden, R. L., Bernardinelli, G., & Escher, S., Helvetica chimica acta, Vol.85(5), 2002, 1246-1260]