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petasites_hybridus_l._gaertn [2015/04/15 10:56] andreas |
petasites_hybridus_l._gaertn [2022/04/09 15:18] (aktuell) andreas |
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Petasites hybridus (L.) G.Gaertn. - syn.Petasites officinalis Moench; Tussilago hybrida L. - Asteraceae \\ | Petasites hybridus (L.) G.Gaertn. - syn.Petasites officinalis Moench; Tussilago hybrida L. - Asteraceae \\ | ||
- | (common) butterbur, **(Gewöhnliche) Pestwurz** | + | (common) butterbur, bog-rhubarb, **(Gewöhnliche) Pestwurz** |
- | Dioecious perennial herb, native to Europe and Western Asia; flowers white to pink-purple, | + | Dioecious perennial herb, up to 60cm high, native to Europe and Western Asia; flowers white to pink-purple, |
"The plants are functionally dioecious, the staminate flowers without rays but marginal pistillate ones often with conspicuous though relatively short rays. Pistillate heads may have numerous rays." \\ | "The plants are functionally dioecious, the staminate flowers without rays but marginal pistillate ones often with conspicuous though relatively short rays. Pistillate heads may have numerous rays." \\ | ||
[[http:// | [[http:// | ||
"Three spasmolytically active substances which contain no nitrogen, namely [[https:// | "Three spasmolytically active substances which contain no nitrogen, namely [[https:// | ||
- | [Über Inhaltsstoffe ausPetasites officinalis Moench I. Petasin und die Petasolester B und C., Stoll, A., Morf, R., Rheiner, A., Renz, J., Experientia, | + | [Über Inhaltsstoffe ausPetasites officinalis Moench I. Petasin und die Petasolester B und C., Stoll, A., Morf, R., Rheiner, A., Renz, J., Experientia, |
- | " | + | " |
[On terpenes. CXXXVIII. Sesquiterpenic hydrocarbons from coltsfoot rhizomes (Petasites officinalis MOENCH.)., Hochmannova, | [On terpenes. CXXXVIII. Sesquiterpenic hydrocarbons from coltsfoot rhizomes (Petasites officinalis MOENCH.)., Hochmannova, | ||
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"Here, we investigated the effects of a plant extract of petasites hybridus (Ze339) and its isolated active sesquiterpene ester petasin in these two in vitro cell models. Zileuton, a 5-lipoxygenase inhibitor, was used as a positive control. All compounds inhibited both cysteinyl-LT synthesis in eosinophils and LTB4 synthesis in neutrophils. In contrast, only Ze339 and petasin, but not zileuton, abrogated PAF- and C5a-induced increases in intracellular calcium concentrations. These data suggest that Ze339 and petasin may block, compared to zileuton, earlier signalling events initiated by G protein-coupled receptors in granulocytes, | "Here, we investigated the effects of a plant extract of petasites hybridus (Ze339) and its isolated active sesquiterpene ester petasin in these two in vitro cell models. Zileuton, a 5-lipoxygenase inhibitor, was used as a positive control. All compounds inhibited both cysteinyl-LT synthesis in eosinophils and LTB4 synthesis in neutrophils. In contrast, only Ze339 and petasin, but not zileuton, abrogated PAF- and C5a-induced increases in intracellular calcium concentrations. These data suggest that Ze339 and petasin may block, compared to zileuton, earlier signalling events initiated by G protein-coupled receptors in granulocytes, | ||
[Role of petasin in the potential anti-inflammatory activity of a plant extract of Petasites hybridus., Thomet, O.A., Wiesmann, U.N., Schapowal, A., Bizer, C., Simon, H.U., Biochemical pharmacology, | [Role of petasin in the potential anti-inflammatory activity of a plant extract of Petasites hybridus., Thomet, O.A., Wiesmann, U.N., Schapowal, A., Bizer, C., Simon, H.U., Biochemical pharmacology, | ||
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+ | "The sesquiterpenes inhibit the formation of leucotrienes and exhibit spasmolytic and analgesic properties. Controlled clinical studies show a positive effect in the tretment of patients with chronic headache and migraine." | ||
+ | [Medicinal Plants of the World. Ben-Erik Van Wyk and Michael Wink, Pretoria 2004, 234] | ||
There are two varieties with different chemical compositions, | There are two varieties with different chemical compositions, | ||
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[Petasol butenoate complex (Ze 339) relieves allergic rhinitis–induced nasal obstruction more effectively than desloratadine., | [Petasol butenoate complex (Ze 339) relieves allergic rhinitis–induced nasal obstruction more effectively than desloratadine., | ||
- | {{: | + | {{: |
Blackwell, E., Herbarium Blackwellianum, | Blackwell, E., Herbarium Blackwellianum, | ||
[[http:// | [[http:// | ||
- | {{: | + | {{: |
+ | Petasites hybridus [[https:// |