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pelargonium_sidoides_dc

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Pelargonium sidoides DC. - syn. Geranium sidaefolium Thunb.; Pelargonium sidaefolium (Thunb.) R.Knuth - Geraniaceae
kalwerbossie (africans), umckaloabo, South African geranium, Kapland-Pelargonie

Shrub-like perennial plant, up to 50cm high, native (endemic) to South Africa; leaves crowded, greyish-green, heart-shaped; flowers reddish-purple (almost black).
http://www.pelargonium-sidoides.com/origin/botany-and-production/

The root extract (EPs® 7630) contained coumarins like umckalin, 6,8-dihydroxy-5,7-dimethoxycumarin, 5-hydroxy-6,7-dimethoxycumarin-8-sulfate and polyphenols (polyphenol content of ca. 22%) like catechin/epicatechin, gallocatechin/epigallocatechin, gallocatechin-4α,8-epigallocatechin, epicatechin-4β,8-epigallocatechin, gallocatechin-4α,6-gallocatechin and epigallocatechin-4β,8-epicatechin as well as proanthocyanidins (prodelphinidins).
„EPs® 7630 respectively the contained proanthocyanidins reduce the adhesiveness of group A streptococci by up to 47% (at an incubation concentration of 30 µg/ml). Here, the trihydroxylation of the B ring of the flavan-3-ol-subunits is of crucial importance for the activity, while the degree of polymerization plays a subordinate role.
EPs® 7630 has a remarkably high inhibitory activity against neuraminidase (IC50 ca. 1 uGu/ml). The commercially available drugs zanamivir (IC50 ca. 18 µg/ml) and oseltamivir carboxylate (IC50 ca. 54 µg/ml) are considerably less active in the used in vitro model. The enzyme is significantly inhibited by proanthocyanidins, with a minimum chain length of three subunits.“
[Beitrag zur Kenntnis der Inhaltsstoffe und der Wirkung des Pelargonium sidoides Spezialextraktes EPs® 7630., Janecki, A., (Doctoral dissertation, Freie Universität Berlin, Germany), 2013]

„P. sidoides may be effective in alleviating symptoms of acute rhinosinusitis and the common cold in adults, but doubt exists. It may be effective in relieving symptoms in acute bronchitis in adults and children, and sinusitis in adults. The overall quality of the evidence was considered low for main outcomes in acute bronchitis in children and adults, and very low for acute sinusitis and the common cold. Reliable data on treatment for other ARIs were not identified.“
[Pelargonium sidoides extract for treating acute respiratory tract infections., Timmer, A., Günther, J., Motschall, E., Rücker, G., Antes, G., Kern, W.V., The Cochrane Library, 2013] http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006323.pub3/full

pelargonium_sidoides_dc.1448358063.txt.gz · Zuletzt geändert: 2015/11/24 10:41 von andreas