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Lamium album L.- Lamiaceae - white dead nettle, Weiße Taubnessel
Perennial herb, 20-50cm high, native to Eurasia, naturalized in eastern North America; leaves opposite, triangular-ovate, toothed, minutely hispid; flowers white or yellowish-white.
The dried flowers (Lamii albi flos, Flores Lamii albi) are traditionally used as expectorant.
[Medicinal Plants of the World. Ben-Erik Van Wyk and Michael Wink, Pretoria 2004, 187]
Alboside A and B are secoiridoids from Lumium album L. where they co-occur with lamalbid. They are derived from 8-epi-deoxyloganic acid. Caryoptoside is an intermediate in the biosynthesis of lamalbid and alboside B.
[Biosynthesis of iridoid glucosides in Lamium album., Damtoft, S., Jensen, S. R., Nielsen, B. J., Phytochemistry, Vol.31(1), 1992, 135-137]
„Two phenylpropanoid glycosides, a new one, lamalboside (2R-galactosylacteoside) and the known acteoside, the flavonol p-coumaroylglucoside, tiliroside, 5-caffeoylquinic acid (chlorogenic acid), along with rutoside and quercetin and kaempferol 3-O-glucosides were isolated from the flowers of Lamium album. Esters of glycosides were obtained as mixtures of trans/cis isomers. The presence of flavonoid p-coumaroylglucosides links Lamium to other members of the subfamily Lamioideae.“
[Phenylpropanoid esters from Lamium album flowers. Budzianowski, J., Skrzypczak, L., Phytochemistry, Vol.38(4), 1995, 997-1001]
„Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC50 2.31 μM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester, loganin, loganic acid, geniposide, verbenalin, eurostoside, and picroside II exhibited significant anti-HCV entry and anti-infectivity activities.“
[Lamiridosins, hepatitis C virus entry inhibitors from Lamium album., Zhang, H., Rothwangl, K., Mesecar, A. D., Sabahi, A., Rong, L., Fong, H. H., Journal of natural products, Vol.72(12), 2009, 2158-2162] http://www.lamiridosin.eu/descargas/HCV_Inhibitors.pdf
