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--- jacobaea_vulgaris_gaertn [2015/03/13 12:01]
andreas
+++ jacobaea_vulgaris_gaertn [2015/06/13 11:38]
127.0.0.1 Externe Bearbeitung
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 "The hepatotoxic alkaloids known to occur in tansy ragwort (Senecio jacobaea L.) are also present in honey produced from the nectar of this species. These alkaloids, which inclued senecionine, seneciphylline, jacoline, jaconine, jacobine, and jacozine, are potentially carcinogenic, mutagenic, and teratogenic and may pose health hazards to the human consumer." \\
 [Pyrrolizidine alkaloids: their occurrence in honey from tansy ragwort (Senecio jacobaea L.)., Deinzer, M.L., Thomson, P.A., Burgett, D.M., Isaacson, D.L., Science, 195(4277), 1977, 497-499]
+"Dried tansy ragwort, which contains pyrrolizidine alkaloids, was fed as 25% of a complete diet to goat kids and to lactating dairy goats. Of 11 animals, 4 died, showing signs of chronic pyrrolizidine alkaloid poisoning, including hepatocellular degeneration, hepatocyte swelling, megalocytosis, and bile duct proliferation. The chronic lethal dose of the dried, ground plant ranged from 1.2 to 4 kg/kg of body weight. Goats were more resistant to tansy ragwort toxicosis than cattle and horses, in which intakes of 0.05 to 0.20 kg/kg of body weight are lethal." \\
+[Toxicity of tansy ragwort (Senecio jacobaea) to goats., Goeger, D.E., Cheeke, P.R., Schmitz, J.A., Buhler, D.R., American journal of veterinary research, Vol.43(2), 1982, 252-254]
 Plants contain jacobine (41-100% of total PA), seldom jacoline (45%) as main PA.

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