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glycyrrhiza_uralensis_fisch._ex_dc

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Fabaceae - syn.Glycyrrhiza grandiflora Tausch, Glycyrrhiza viscida Turz. et Bess.; gan tsao, Chinese Licorice, Chinesisches Süßholz

Perennial herb, 30-120cm tall, native from North China to southern Sibiria; stem white or brown tomentose; leaves alternate, odd-pinnate; leaflets ovate, narrowly ovate, or orbicular; inflorescence with short peduncle; corolla purple, white, or yellow. http://www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=200012145

„Liquorice root, or 'radix glycyrrhizae', is one of the 50 fundamental herbs used in traditional Chinese medicine, where it has the name gancao (kan-tsao; Chinese: 甘草). It is usually collected in spring and autumn, when it is removed from the rootlet and dried in the sun. Liquorice root is most commonly produced in the Shanxi, Gansu and Xinjiang regions of China.“ http://en.wikipedia.org/wiki/Glycyrrhiza_uralensis

„About the six main constituents of licorice of glycyrrhizin, liquiritin, liquiritin apioside, isoliquiritin, soliquiritin apioside, and liquiritigenin, the constituent property of G.glabra resembles to that of G.inflata, but that of G.uralensis does not resemble to that of G.glabra or G.inflata and is characterized by a wider content variation of the six main constituents of licorice than that of G.glabra or G.inflata. The mean contents of liquiritin, isoliquiritin, and liquilitigenin in G.uralensis are significantly higher than those of G.glabra and G.inflata. Especially, the mean contet of liquiritin in G.uralensis is higher more than 1% compared to that of G.glabra or G.inflata. Additionally, glycycoumarin, glabridin, or licochalcone A are reconfirmed as the species-specific constituents for G.uralensis, G.glabra, or G.inflata respectively.“
[Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information. Kondo, K., Shiba, M., Nakamura, R., Morota, T., & Shoyama, Y. , Biological and Pharmaceutical Bulletin, Vol.30(7), 2007, 1271-1277]

Glycyrol is an important anti-inflammatory constituent of Glycyrrhizae Radix, and its anti-inflammatory effect is attributed to the inhibition I-κBα phosphorylation.
[Anti-inflammatory effects of glycyrol isolated from Glycyrrhiza uralensis in LPS-stimulated RAW264.7 macrophages, Eun Myoung Shin et al., International Immunopharmacology, Vol.8(11), 2008, 1524–1532]

Isoliquiritigenin (IC50 = 9.0 μM) and glycyrol (IC50 = 3.1 μM) from G.uralensis have strong neuraminidase inhibitor activity.
[Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis. Ryu, Y. B., Kim, J. H., Park, S. J., Chang, J. S., Rho, M. C., Bae, K. H., … & Lee, W. S., Bioorganic & medicinal chemistry letters, Vol.20(3), 2010, 971-974]

glycyrol

glycyrrhiza_uralensis_fisch._ex_dc.1407059494.txt.gz · Zuletzt geändert: 2014/08/03 11:51 von andreas