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--- galega_officinalis_l [2015/07/19 15:05]
andreas
+++ galega_officinalis_l [2015/07/19 15:32]
andreas
@@ Zeile 4: / Zeile 4: @@
 [[http://www.efloras.org/florataxon.aspx?flora_id=5&taxon_id=220005407]]
-"Galegine was isolated as an active anti-hyperglycemic agent from the plant Galega officinalis L. This plant was used ethnomedically for the treatment of diabetes. Galegine provided the template for the synthesis of metformin and opened up interest in the synthesis of other biguanidine-type antidiabetic drugs." \\
+"[[http://pubchem.ncbi.nlm.nih.gov/compound/Galegine#section=Top|Galegine]] was isolated as an active anti-hyperglycemic agent from the plant Galega officinalis L. This plant was used ethnomedically for the treatment of diabetes. Galegine provided the template for the synthesis of metformin and opened up interest in the synthesis of other biguanidine-type antidiabetic drugs." \\
 [The value of plants used in traditional medicine for drug discovery., Fabricant, D.S., Farnsworth, N.R., Environmental health perspectives, 109(Suppl 1), 2001, 69] [[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240543/pdf/ehp109s-000069.pdf]]
+{{:galegine.jpg|}}  galegine
 "A fraction isolated from crude aqueous extract of Galega officinalis L. and purified by column chromatography inhibit platelet aggregation in platelet-rich plasma. The active fraction of the extract, molecular weight of 100–140 kDa, appeared to be polysaccharide-protein complex. Aggregation of platelets initiated by 25 μM ADP was inhibited 50 percent by 11.2 μg/ml of the fraction. Aggregation of platelets initiated by 100 μg/ml collagen and 0.8 U/ml thrombin was completely inhibited by 16 μg/ml and 18.3 μg/ml, respectively." \\

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