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--- eschscholzia_californica_cham [2015/04/26 12:16]
andreas
+++ eschscholzia_californica_cham [2015/07/04 19:10] (aktuell)
andreas
@@ Zeile 13: / Zeile 13: @@
 [Behavioural effects of the American traditional plant Eschscholzia californica: sedative and anxiolytic properties., Rolland, A., Fleurentin, J., Lanhers, M.C., Younos, C., Misslin, R., Mortier, F., Pelt, J.M., Planta medica, Vol.57(3), 1991, 212]
-The herb contains alkaloids (0.29-0.38%), mainly californidine (0.19-0.23%, N-methylated escholtzine) and tertiary nonphenolic bases (0.14-0.15%) like allocryptopine (0.02-0.03%), protopine and escholtzine. \\
+The herb contains alkaloids (0.29-0.38%), mainly [[https://en.wikipedia.org/wiki/Californidine|californidine]] (0.19-0.23%, N-methylated escholtzine) and tertiary nonphenolic bases (0.14-0.15%) like allocryptopine (0.02-0.03%), protopine and escholtzine. \\
 [Hagers Handbuch der Pharmazeutischen Praxis, Springer 2010]
-"A 70% ethanol extract of California poppy (Eschscholzia californica) was able to bind to 5-HT1A and 5-HT7 receptors at 100 μg/mL. The subsequent isolation procedure yielded the known alkaloids californidine (1), escholtzine (2), N-methyllaurotetanine (3), caryachine (4), and O-methylcaryachine (5), along with a new pavine alkaloid, 6S,12S-neocaryachine-7-O-methyl ether N-metho salt (7). The structure of 7 was determined by spectroscopic data interpretation, while the absolute stereochemistry was determined by means of circular dichroism. From the results obtained from the radioligand-binding assay of the pure compounds, including the commercially available protopine (6), it was evident that the activity on the 5-HT1A receptor was at least partly due to the presence of the aporphine alkaloid 3, which showed the highest inhibition of [3H]8-hydroxy-2-(di-N-propylamino)tetralin ([3H]8-OH-DPAT) binding with an EC50 value of 155 nM and a Ki of 85 nM." \\
+"A 70% ethanol extract of California poppy (Eschscholzia californica) was able to bind to 5-HT1A and 5-HT7 receptors at 100 μg/mL. The subsequent isolation procedure yielded the known alkaloids californidine (1), escholtzine (2), [[http://chem.sis.nlm.nih.gov/chemidplus/rn/2169-44-0|N-methyllaurotetanine]] (3), caryachine (4), and O-methylcaryachine (5), along with a new pavine alkaloid, 6S,12S-neocaryachine-7-O-methyl ether N-metho salt (7). The structure of 7 was determined by spectroscopic data interpretation, while the absolute stereochemistry was determined by means of circular dichroism. From the results obtained from the radioligand-binding assay of the pure compounds, including the commercially available protopine (6), it was evident that the activity on the 5-HT1A receptor was at least partly due to the presence of the aporphine alkaloid 3, which showed the highest inhibition of [3H]8-hydroxy-2-(di-N-propylamino)tetralin ([3H]8-OH-DPAT) binding with an EC50 value of 155 nM and a Ki of 85 nM." \\
 [Alkaloids from Eschscholzia c alifornica and Their Capacity to Inhibit Binding of [3H] 8-Hydroxy-2-(di-N-propylamino) tetralin to 5-HT1A Receptors in Vitro., Gafner, S., Dietz, B.M., McPhail, K.L., Scott, I.M., Glinski, J.A., Russell, F.E., Bolton, J.L., Journal of natural products, Vol.69(3), 2006, 432-435]
@@ Zeile 23: / Zeile 23: @@
 [[http://plantgenera.org/species.php?id_species=408833]]
+{{:esch_calif_botg.jpg?600}}

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