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echinacea_pallida_nutt._nutt [2015/11/04 12:14]
andreas |
echinacea_pallida_nutt._nutt [2015/11/04 13:27]
andreas |
| pale echinacea, pale purple-coneflower, pale-flower echinacea, **Blassfarbener Sonnenhut**, Prärie-Igelkopf, Blasser Igelkopf, Blassfarbene Kegelblume | pale echinacea, pale purple-coneflower, pale-flower echinacea, **Blassfarbener Sonnenhut**, Prärie-Igelkopf, Blasser Igelkopf, Blassfarbene Kegelblume |
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| Perennial herb, up to 1m high, native in central North America, naturalized in eastern North America, also cultivated; sparsely to densely hairy, stems green to purplish (rarely branched); leaves elliptic to lanceolate, entire, flower rays pink to pale reddish purple, laminae reflexed, up to 9cm long; disc corollas 5-7mm, lobes usually pink to purple, pollen usually white, rarely lemon yellow; cypselae tan or bicolored, 2.5-5mm. [[http://www.efloras.org/florataxon.aspx?flora_id=1&taxon_id=242416464]] | Perennial herb, up to 1m high, native in central North America, naturalized in eastern North America, also cultivated; sparsely to densely hairy, stems green to purplish (rarely branched); leaves elliptic to lanceolate, entire; paleae 9-14mm, tips purple, sharp-pointed; rays pink to pale reddish purple, laminae reflexed, up to 9cm long; disc corollas 5-7mm, lobes usually pink to purple, pollen usually white, rarely lemon yellow; cypselae tan or bicolored, 2.5-5mm. [[http://www.efloras.org/florataxon.aspx?flora_id=1&taxon_id=242416464]] |
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| "Preparations and extracts are taken orally and used in supportive therapy for colds and influenze. In Germany, only E.pallida is an approved herb, not E.angustifolia... The immun stimulant effects are mainly derived from in vitro experiments with immune cells, showing increased mobility and phagocytosis... Controlled clinical studies with patients suffering from flu have shown efficacy for the stated indications; the duration of illness was significantly shortened." \\ | "Preparations and extracts are taken orally and used in supportive therapy for colds and influenze. In Germany, only E.pallida is an approved herb, not E.angustifolia... The immun stimulant effects are mainly derived from in vitro experiments with immune cells, showing increased mobility and phagocytosis... Controlled clinical studies with patients suffering from flu have shown efficacy for the stated indications; the duration of illness was significantly shortened." \\ |
| "Bioassay-guided fractionation of n-hexane extracts of Echinacea pallida (Asteraceae) roots led to the isolation and structure elucidation of two polyacetylenes (1, 3) and three polyenes (2, 4, 5). Two are known hydroxylated compounds, namely 8-hydroxy-pentadeca-(9E)-ene-11,13-diyn-2-one (1) and 8-hydroxy-pentadeca-(9E,13Z)-dien-11-yn-2-one (2). Two dicarbonylic constituents, namely pentadeca-(9E)-ene-11,13-diyne-2,8-dione (3) and pentadeca-(9E,13Z)-dien-11-yne-2,8-dione (4), were isolated and characterized for the first time. Furthermore, the structure elucidation of pentadeca-(8Z,13Z)-dien-11-yn-2-one (5) is described." \\ | "Bioassay-guided fractionation of n-hexane extracts of Echinacea pallida (Asteraceae) roots led to the isolation and structure elucidation of two polyacetylenes (1, 3) and three polyenes (2, 4, 5). Two are known hydroxylated compounds, namely 8-hydroxy-pentadeca-(9E)-ene-11,13-diyn-2-one (1) and 8-hydroxy-pentadeca-(9E,13Z)-dien-11-yn-2-one (2). Two dicarbonylic constituents, namely pentadeca-(9E)-ene-11,13-diyne-2,8-dione (3) and pentadeca-(9E,13Z)-dien-11-yne-2,8-dione (4), were isolated and characterized for the first time. Furthermore, the structure elucidation of pentadeca-(8Z,13Z)-dien-11-yn-2-one (5) is described." \\ |
| [Isolation and structure elucidation of cytotoxic polyacetylenes and polyenes from Echinacea pallida., Pellati, F., Calò, S., Benvenuti, S., Adinolfi, B., Nieri, P., Melegari, M., Phytochemistry, 67(13), 2006, 1359-1364] | [Isolation and structure elucidation of cytotoxic polyacetylenes and polyenes from Echinacea pallida., Pellati, F., Calò, S., Benvenuti, S., Adinolfi, B., Nieri, P., Melegari, M., Phytochemistry, 67(13), 2006, 1359-1364] |
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| | {{:pentadeca8z13zdien11yn2one.jpg| pentadeca-(8Z,13Z)-dien-11-yn-2-one }} pentadeca-(8Z,13Z)-dien-11-yn-2-one |
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| Cytotoxic acetylenes are present in E. pallida lipophilic extracts but essentially absent in extracts from E.angustifolia and E.purpurea. Bioassay-guided fractionation of the n-hexane extract of E. pallida roots lead to the isolation of 8-hydroxy-pentadeca-(9E)-ene-11,13-diyn-2-one, pentadeca-(9E)-ene-11,13-diyne-2,8-dione, 8-hydroxy-pentadeca-(9E,13Z)-dien-11-yn-2-one, pentadeca-(9E,13Z)-dien-11-yne-2,8-dione and pentadeca-(8Z,13Z)-dien-11-yn-2-one. Apoptotic cell death was found to be involved in the cytotoxic effect of the most active compound, pentadeca-(8Z,13Z)-dien-11-yn-2-one. \\ | Cytotoxic acetylenes are present in E. pallida lipophilic extracts but essentially absent in extracts from E.angustifolia and E.purpurea. Bioassay-guided fractionation of the n-hexane extract of E. pallida roots lead to the isolation of 8-hydroxy-pentadeca-(9E)-ene-11,13-diyn-2-one, pentadeca-(9E)-ene-11,13-diyne-2,8-dione, 8-hydroxy-pentadeca-(9E,13Z)-dien-11-yn-2-one, pentadeca-(9E,13Z)-dien-11-yne-2,8-dione and pentadeca-(8Z,13Z)-dien-11-yn-2-one. Apoptotic cell death was found to be involved in the cytotoxic effect of the most active compound, pentadeca-(8Z,13Z)-dien-11-yn-2-one. \\ |
