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cicuta_virosa_l [2015/01/15 09:14]
andreas |
cicuta_virosa_l [2018/06/07 16:26]
andreas |
| Very poisonous perennial herb, 0.60-1.20m tall, native to the northern hemisphere; leaves bi- or tripinnate; flowers small, white, umbellules 15-35 flowered. | Very poisonous perennial herb, 0.60-1.20m tall, native to the northern hemisphere; leaves bi- or tripinnate; flowers small, white, umbellules 15-35 flowered. |
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| "The effect of [[http://en.wikipedia.org/wiki/Cicutoxin|cicutoxin]], the poisonous principle of the genus Cicuta, on K+currents of activated T lymphocytes was investigated using the patch clamp technique. Cicutoxin produced a dose-dependent [5 × 10− 6–7 × 10−5mol/l] and completely reversible block of K+currents with an EC50 of 1.8 × 10−5mol/l. A maximum block of 71% was achieved with cicutoxin at a concentration of 7 × 10−5mol/l. Since previous studies have shown that T lymphocyte proliferation is associated with K+currents, the effect of cicutoxin on T lymphocyte proliferation was studied by means of 3H-thymidine uptake assays. At noncytotoxic concentrations [10−7−5 × 10−5mol/l] cicutoxin reduced the3H-thymidine incorporation dose-dependently. In conclusion, cicutoxin is a potent K+current blocker which inhibits K+channel-dependent proliferation of naive and memory T lymphocytes." \\ | "[[http://en.wikipedia.org/wiki/Cicutoxin|Cicutoxin]] is the most poisonous and most important component of polyynes of water hemlock (Cicuta virosa). It is found in all plant parts (highest content: rhizome up to 0.2%). Related compounds in water hemlock are isocicutoxin (Z-isomer of cicutoxin), with about 25%, and virol A and B, each with about 3% share of the total polyyne content." [[http://de.wikipedia.org/wiki/Cicutoxin]] |
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| | "The effect of cicutoxin, the poisonous principle of the genus Cicuta, on K+currents of activated T lymphocytes was investigated using the patch clamp technique. Cicutoxin produced a dose-dependent [5 × 10− 6–7 × 10−5mol/l] and completely reversible block of K+currents with an EC50 of 1.8 × 10−5mol/l. A maximum block of 71% was achieved with cicutoxin at a concentration of 7 × 10−5mol/l. Since previous studies have shown that T lymphocyte proliferation is associated with K+currents, the effect of cicutoxin on T lymphocyte proliferation was studied by means of 3H-thymidine uptake assays. At noncytotoxic concentrations [10−7−5 × 10−5mol/l] cicutoxin reduced the3H-thymidine incorporation dose-dependently. In conclusion, cicutoxin is a potent K+current blocker which inhibits K+channel-dependent proliferation of naive and memory T lymphocytes." \\ |
| [Cicutoxin from Cicuta virosa —A New and Potent Potassium Channel Blocker in T Lymphocytes., Strauß, U., Wittstock, U., Schubert, R., Teuscher, E., Jung, S., Mix, E., Biochemical and biophysical research communications, Vol.219(2), 1996, 332-336] | [Cicutoxin from Cicuta virosa —A New and Potent Potassium Channel Blocker in T Lymphocytes., Strauß, U., Wittstock, U., Schubert, R., Teuscher, E., Jung, S., Mix, E., Biochemical and biophysical research communications, Vol.219(2), 1996, 332-336] |
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| [Poisoning due to water hemlock., Schep, L.J., Slaughter, R.J., Becket, G., Beasley, D.M.G., Clinical toxicology, Vol.47(4), 2009, 270-278] | [Poisoning due to water hemlock., Schep, L.J., Slaughter, R.J., Becket, G., Beasley, D.M.G., Clinical toxicology, Vol.47(4), 2009, 270-278] |
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| {{http://upload.wikimedia.org/wikipedia/commons/1/17/Cicuta_virosa_-_K%C3%B6hler%E2%80%93s_Medizinal-Pflanzen-038_cropped.jpg}} | {{cicuta_virosa.jpg?600}} \\ |
| | [Cicuta virosa L.; Köhler, F.E., Medizinal Pflanzen, vol.3 t.21 (1890)] |
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| | {{http://www.botanische-spaziergaenge.at/Bilder/Lumix_92/P1140646.JPG}} \\ |
| | Cicuta virosa, Garten Tulln © Rolf Marschner (2018), [[http://botanische-spaziergaenge.at/viewtopic.php?f=574&t=4835| www.botanische-spaziergaenge.at]] |
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