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caulophyllum_thalictroides_l._michx

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caulophyllum_thalictroides_l._michx [2015/09/12 16:22]
andreas
caulophyllum_thalictroides_l._michx [2015/09/12 16:28] (aktuell)
andreas
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 "The plant contains the alkaloids N-methylcytisine,​ baptifoline,​ anagyrine and magnoflorine. Some of the alkaloids, including the quinolizidine alkaloid anagyrine, are toxic to range animals and have been implicated as teratogens in higher animals. Since the traditional use of the herb involves administration to women of reproductive age to treat menstrual cramps, and to pregnant women in the last 3-4 weeks of pregnancy to ease parturition,​ therefore the safety of these products to the fetus is of concern. Three of these alkaloids have been determined in authentic blue cohosh and several dietary supplements. Levels found were: 5-850 ppm for N-methylcytisine,​ 2-390 ppm for anagyrine, and 9-900 ppm for baptifoline. The lower alkaloid concentrations were found in products containing liquid extracts.""​ \\ "The plant contains the alkaloids N-methylcytisine,​ baptifoline,​ anagyrine and magnoflorine. Some of the alkaloids, including the quinolizidine alkaloid anagyrine, are toxic to range animals and have been implicated as teratogens in higher animals. Since the traditional use of the herb involves administration to women of reproductive age to treat menstrual cramps, and to pregnant women in the last 3-4 weeks of pregnancy to ease parturition,​ therefore the safety of these products to the fetus is of concern. Three of these alkaloids have been determined in authentic blue cohosh and several dietary supplements. Levels found were: 5-850 ppm for N-methylcytisine,​ 2-390 ppm for anagyrine, and 9-900 ppm for baptifoline. The lower alkaloid concentrations were found in products containing liquid extracts.""​ \\
 [Gas chromatographic determination of toxic quinolizidine alkaloids in blue cohosh Caulophyllum thalictroides (L.) Michx., Betz, J.M., Andrzejewski,​ D., Troy, A., Casey, R.E., Obermeyer, W.R., Page, S.W., Woldemariam,​ T.Z., Phytochemical Analysis, 9(5), 1998, 232-236] [Gas chromatographic determination of toxic quinolizidine alkaloids in blue cohosh Caulophyllum thalictroides (L.) Michx., Betz, J.M., Andrzejewski,​ D., Troy, A., Casey, R.E., Obermeyer, W.R., Page, S.W., Woldemariam,​ T.Z., Phytochemical Analysis, 9(5), 1998, 232-236]
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 +"A newborn infant whose mother ingested an herbal medication, blue cohosh, to promote uterine contractions presented with acute myocardial infarction associated with profound congestive heart failure and shock. The infant remained critically ill for several weeks, although he eventually recovered. Other causes of myocardial infarction were carefully excluded. Blue cohosh, Caulophyllum thalictroides,​ contains vasoactive glycosides and an alkaloid known to produce toxic effects on the myocardium of laboratory animals."​ \\
 +[Profound neonatal congestive heart failure caused by maternal consumption of blue cohosh herbal medication.,​ Jones, T.K., Lawson, B.M., The Journal of pediatrics, 132(3), 1998, 550-552]
  
 Blue cohosh rhizomes and roots contain two kinds of triterpene saponins with caulosapogenin and hederagenin as aglycones. Sugar parts are made of α-L-arabinose,​ β-D-glucose,​ and α-L-rhamnose. \\ Blue cohosh rhizomes and roots contain two kinds of triterpene saponins with caulosapogenin and hederagenin as aglycones. Sugar parts are made of α-L-arabinose,​ β-D-glucose,​ and α-L-rhamnose. \\
 [Characterization of the triterpene saponins of the roots and rhizomes of blue cohosh (Caulophyllum thalictroides).,​ Jhoo, J.W., Sang, S., He, K., Cheng, X., Zhu, N., Stark, R.E., Ho, C.T., Journal of agricultural and food chemistry, 49(12), 2001, 5969-5974] [[http://​www.sci.ccny.cuny.edu/​resgroup/​uploaded/​Rresepubl1091814752_jf010814e.pdf]] [Characterization of the triterpene saponins of the roots and rhizomes of blue cohosh (Caulophyllum thalictroides).,​ Jhoo, J.W., Sang, S., He, K., Cheng, X., Zhu, N., Stark, R.E., Ho, C.T., Journal of agricultural and food chemistry, 49(12), 2001, 5969-5974] [[http://​www.sci.ccny.cuny.edu/​resgroup/​uploaded/​Rresepubl1091814752_jf010814e.pdf]]
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 +"A 21-y-old female developed tachycardia,​ diaphoresis,​ abdominal pain, vomiting and muscle weakness and fasciculations after using blue cohosh (Caulophyllum thalictroides) in an attempt to induce an abortion. These symptoms are consistent with nicotinic toxicity and probably resulted from methylcytisine known present in blue cohosh. The patient'​s symptoms resolved over 24 h and she was discharged. Whether successful or not, the use of natural agents to induce abortion is frequently associated with adverse effects in the mother or fetus. Clinicians should recognize the potential toxicity of these agents."​ \\
 +[Nicotinic toxicity from tincture of blue cohosh (Caulophyllum thalictroides) used as an abortifacient.,​ Rao, R.B., Hoffman, R.S., Veterinary and human toxicology, 44(4), 2002, 221-222] ​
  
 "Blue cohosh is also referred to as “papoose root” or “squaw root”, which reflects the use of this herbal medicine by Native American women who brewed blue cohosh as a tea to relieve menstrual cramps and to ease the  pains associated with childbirth... Based on the available scientific information,​ blue cohosh should 1) be used with extreme caution during pregnancy, 2) be used only under medical professional supervision and 3) not be available to the public as an over-the-counter product."​ \\ "Blue cohosh is also referred to as “papoose root” or “squaw root”, which reflects the use of this herbal medicine by Native American women who brewed blue cohosh as a tea to relieve menstrual cramps and to ease the  pains associated with childbirth... Based on the available scientific information,​ blue cohosh should 1) be used with extreme caution during pregnancy, 2) be used only under medical professional supervision and 3) not be available to the public as an over-the-counter product."​ \\
caulophyllum_thalictroides_l._michx.txt · Zuletzt geändert: 2015/09/12 16:28 von andreas