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Buxaceae - European box, common box, Buchsbaum
Evergreen shrub or small tree, native in Europe, Mediterranean, North Africa, West Asia; 0.30-4m, as tree up to 8m; leaves ovate, emarginate,leathery; flowers yellowish-white.
„… extracts of the aerial parts of Buxus sempervirens growing naturally in Turkey were investigated against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) as well as tyrosinase (TYRO) enzymes for their inhibitory activity using ELISA microplate reader. Antiprotozoal activity of the extracts was tested against the parasites; Plasmodium falciparum (malaria) and Trypanosoma brucei rhodesiense (human African trypanosomiasis) at 0.81 and 4.85 μg/mL concentrations. As antioxidant activity contributes to antimalarial activity, the extracts were also tested for their 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, iron-chelating capacity, and ferric-reducing antioxidant power (FRAP). Total phenol and flavonoid contents in the extracts were determined spectrophotometrically. The alkaloid fraction of the chloroform extract afforded two major alkaloids named (+)-buxabenzamidienine (1) and (+)-buxamidine (2). Our results showed that, except for the petroleum ether extract, the extracts displayed high antimalarial and anti-BChE effects as well as quite high iron-chelation capacity.“ [Exploration of cholinesterase and tyrosinase inhibitory, antiprotozoal and antioxidant effects of Buxus sempervirens L. (boxwood), Orhan Ilkay Erdogan, Erdem Sinem Aslan, Senol Fatma Sezer, Kartal Murat, Sener Bilge, Industrial Crops and Products, Vol.40, 2012, 116-121]