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bacopa_monnieri_l._pennell

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Bacopa monnieri (L.) Pennell - syn.Gratiola monnieria L.; Lysimachia monnieri L. - Plantaginaceae
brahmi, bacopa, water hyssop, herb of grace, Kleines Fettblatt

Succuleent creeping herb, native to India and Southeast Asia; leaves sessile, entire, oblong-oblanceolate; flowers axillary, white, blue, or purple; fruit a narrowly ovoid capsule; seeds yellow-brown.
http://www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=200020622

„Bacopa has been used in traditional Ayurvedic treatment for epilepsy and asthma.“
https://en.wikipedia.org/wiki/Bacopa_monnieri

The putative bioactive component, Bacoside A, was found to be a mixture of saponins with bacoside A3 (0.1-0.8%), bacopaside II (0.1-0-6%), jujubogenin isomer of bacopasaponin C (0.05-0.7%) and bacopasaponin C (0.05-0.4%) as major constituents. Two common flavonoids, luteolin and apigenin, were also present in all samples.
[Quantitative determination of the major saponin mixture bacoside A in Bacopa monnieri by HPLC., Deepak, M., Sangli, G.K., Arun, P.C., Amit, A., Phytochemical Analysis, Vol.16(1), 2005, 24-29]

„Several Bacopa samples (plant materials, extracts and commercial formulations) were successfully analyzed. Major bacopasaponins were bacosides A3 (3), bacopaside II (4), bacopaside I (5), bacopaside X (6), bacopasaponin C (7), bacopaside N2 (9) and the minor components were bacopasaponin F (1), bacopasaponin E (2), bacopaside N1 (8) bacopaside III (10), bacopaside IV (11) and bacopaside V (12). The total saponin content in the samples, plant materials and extracts varied from 5.1 to 22.17% and 1.47 to 66.03 mg/capsule or tablet in the commercial formulations.“
[Estimation of twelve bacopa saponins in Bacopa monnieri extracts and formulations by high-performance liquid chromatography., Murthy, P.B.S., Raju, V.R., Ramakrisana, T., Chakravarthy, M.S., Kumar, K.V., Kannababu, S., Subbaraju, G.V., Chemical and pharmaceutical bulletin, Vol.54(6), 2006, 907-911]

Using oxygen- and glucose-deprivation (OGD)-induced hippocampal cell damage as an in vitro model of ischemia, bacopaside I (25 μM) exhibited potent neuroprotective effects against OGD-induced neuronal cell damage. „OGD caused necrosis and apoptosis and… bacopaside I attenuated the effects of OGD. The neuroprotective effects of bacopaside I were blocked by the PKC inhibitor Ro-31-8220 and PI3K inhibitor LY294002, but not by the ERK inhibitor U0126.“
[Protective effects of Bacopa monnieri on ischemia-induced cognitive deficits in mice: The possible contribution of bacopaside I and underlying mechanism., Le, X. T., Pham, H. T. N., Van Nguyen, T., Nguyen, K. M., Tanaka, K., Fujiwara, H., Matsumoto, K., Journal of ethnopharmacology, Vol.164, 2015, 37-45]

bacopa.jpg
Roxburgh, W., Plants of the coast of Coromandel, vol.2, t.178 (1798) [n.a.]
http://plantgenera.org/species.php?id_species=124153

bacopa_monnieri_l._pennell.1434188239.txt.gz · Zuletzt geändert: 2016/12/16 10:25 (Externe Bearbeitung)