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atractylodes_macrocephala_koidz [2015/05/29 10:42]
andreas
atractylodes_macrocephala_koidz [2015/06/13 11:37] (aktuell)
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 "To study the diuretic effect of different doses of Atractylodes Macrocephala decoction on different water load mice. The results showed that the decoction didn't present the diuretic function to normal mice treated only once, moderate dose and high dose of the decoction had the antidiuretic function. High dose of the decoction can markedly enhance the rating of cleaning the normal saline away in abdominal cavity, but low dose markedly inhibit that. Conclusion:​The effect of drying dampness and diuresis of Atractylodes Macrocephala is not related to diuretic effect, its peritoneal absorption function is suggested."​ \\ "To study the diuretic effect of different doses of Atractylodes Macrocephala decoction on different water load mice. The results showed that the decoction didn't present the diuretic function to normal mice treated only once, moderate dose and high dose of the decoction had the antidiuretic function. High dose of the decoction can markedly enhance the rating of cleaning the normal saline away in abdominal cavity, but low dose markedly inhibit that. Conclusion:​The effect of drying dampness and diuresis of Atractylodes Macrocephala is not related to diuretic effect, its peritoneal absorption function is suggested."​ \\
 [Experimental Study on the Effect of Drying Dampness and Diuresis of Atractylodes Macrocephala [J]., Shi, W.R., Liu, Y., Chen, L., Journal of Fujian College of Traditional Chinese Medicine, Vol.3, 2007, 12] [Experimental Study on the Effect of Drying Dampness and Diuresis of Atractylodes Macrocephala [J]., Shi, W.R., Liu, Y., Chen, L., Journal of Fujian College of Traditional Chinese Medicine, Vol.3, 2007, 12]
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-"In an attempt to elucidate the physiological activities of (6E, 12E)-tetradecadiene-8,​ 10-diyne-1, 3-diol diacetate (TDEYA), which was detected as a hydrolysis form (TDEY) in the plasma after oral administration of a decoction of Atractylodes rhizome in rats, we examined the inhibitory effects of various enzymes which are considered to participate in the regulation of body fluid levels and inflammatory reactions.TDEY and TDEYA did not show inhibitory effects on carbonic anhydrase (CA) or angiotensin converting enzyme (ACE) at concentrations less than 1.0×10-3 M. However, both acetylene compounds inhibited Na+, K+ adenosine triphosphatase (Na+, K+ -ATPase) weakly and xanthine oxidase (XO) strongly.From the results of several acetylene compounds examined on XO inhibition, it is clear that the active structure of the compounds is due to the presence of conjugated triple and double bonds.In the in vivo experiment of TDEYA, urine volume, urinary electrolytes and uric acid excretion showed no significant differences from the control. However, the administration of TDEYA to rats tended to increase xanthine excretion."​ \\ 
-[Enzyme inhibitory activities of acetylene and sesquiterpene compounds in Atractylodes rhizome., Sakurai, T., Yamada, H., Saito, K.I., Kano, Y., Biol. Pharm. Bull, Vol.16(2), 1993, 142-145] 
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-"​Atractylon,​ a major component of the crude drug “Byaku-jutsu” (rhizomes of Atractylodes japonica), strongly inhibited Na+,​K+-ATPase activity with an I50 value of 8.9 × 10−6 M. It also inhibited Mg2+ ATPase, H+,​K+-ATPase,​ H+-ATPase and Ca2+-ATPase activities, but less potently."​ \\ 
-[Specific inhibition of Na+, K+-ATPase activity by atractylon, a major component of Byaku-jutsu,​ by interaction with enzyme in the E 2 state., Satoh, K., Nagai, F., Ushiyama, K., Kano, I., Biochemical pharmacology,​ Vol.51(3), 1996, 339-343] 
  
 "Oral administration of atractylenolide I and 14-acetoxy-12-senecioyloxytetradeca-2E,​8E,​10E-trien-4,​6-diyn-1-ol produced significant anti-inflammatory effects in acute and chronic inflammation models in mice. The screening results with WBCM-C [white blood cell membrane (WBCM) chromatography (WBCM-C)] were correlated significantly with pharmacological effects in vivo. Atractylenolide I and 14-acetoxy-12-senecioyloxytetradeca-2E,​8E,​10E-trien-4,​6-diyn-1-ol were the main components of Atractylodes macrocephala that were effective as anti-inflammatory agents."​ \\ "Oral administration of atractylenolide I and 14-acetoxy-12-senecioyloxytetradeca-2E,​8E,​10E-trien-4,​6-diyn-1-ol produced significant anti-inflammatory effects in acute and chronic inflammation models in mice. The screening results with WBCM-C [white blood cell membrane (WBCM) chromatography (WBCM-C)] were correlated significantly with pharmacological effects in vivo. Atractylenolide I and 14-acetoxy-12-senecioyloxytetradeca-2E,​8E,​10E-trien-4,​6-diyn-1-ol were the main components of Atractylodes macrocephala that were effective as anti-inflammatory agents."​ \\
atractylodes_macrocephala_koidz.txt · Zuletzt geändert: 2015/06/13 11:37 (Externe Bearbeitung)