Dies ist eine alte Version des Dokuments!
Atractylodes lancea (Thunb.) DC. - syn.Atractylodes chinensis (Bunge) Koidz.; Atractylodes japonica Koidz. ex Kitam.; Atractylodes lyrata Siebold & Zucc.; Atractylodes ovata (Thunb.) DC. - Asteraceae
苍术 cāngzhú (chin.), ホソバオケラ hosobaokera (jap.), southern tsangshu, swordlike atractylodes
Atractylodes japonica Koidz. ex Kit. - Wa-byakulu-tsu (jap.), JP XII
Atractylodes ovata DC. - Kara-byakujutsu (jap.), JP XII
Perennial herb, up to 70cm tall, native to East Asia (China, Korea, Japan), cultivated there; leaves alternate, elliptic-lanceolate, up to 4cm long, serrate; flowers white, tinged with purple, terminal.
The dried finger-shaped, roughly monilifrom rhizomes are 3-9cm long, smell somewaht aromatic and own a warm and bitter taste. Indications are oedama and water retention, vomiting and loss of appetite.
[Medicinal plants in China: a selection of 150 commonly used species., World Health Organization., 1989, 48-49]
„Atractylodes lancea Thunb. is a species of Atractylodes that grows in central China. It is one source of cāng zhú, a Chinese herbal medicine that is believed to act primarily on the digestive system.“
https://en.wikipedia.org/wiki/Atractylodes_lancea
„Lipophilic extracts of Atractylodes lancea rhizomes exhibited potent inhibitory activities in 5-lipoxygenase [IC50 (5-LOX) = 2.9 μg/mL (n-hexane extract)] and cyclooxygenase-1 [IC50 (COX-1) = 30.5 μg/mL (n-hexane extract)] enzymatic assays. Bioactivity-guided fractionation of the n-hexane extract led to the isolation of a new compound atractylochromene, a potent inhibitor in both test systems [IC50 (5-LOX) = 0.6 μM, IC50 (COX-1) = 3.3 μM]. Also obtained was 2-[(2E)-3,7-dimethyl-2,6-octadienyl]-6-methyl-2,5-cyclohexadiene-1,4-dione, which showed a selective inhibitory activity against 5-LOX [IC50 (5-LOX) 0.2 μM, IC50 (COX-1) 64.3 μM]. The sesquiterpene atractylon and the coumarin osthol turned out to be moderate but selective 5-lipoxygenase inhibitors. Atractylenolides I, II, and III showed no significant inhibitory effects for either enzyme. Structures were established by spectral data interpretation.“
[5-Lipoxygenase and cyclooxygenase-1 inhibitory active compounds from Atractylodes lancea., Resch, M., Steigel, A., Chen, Z.L., Bauer, R., Journal of natural products, Vol.61(3), 1998, 347-350]