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--- asarum_sieboldii_miq [2015/07/02 08:01]
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+++ asarum_sieboldii_miq [2015/12/22 07:41]
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 [Hager; Fujita Y, Bot.Mag.Tokyo, 79, (1966), 783-790]
-"The methanolic extract of the roots of Asiasarum sieboldi has been evaluated for anti-allergic effects on various experimental models in vitro and in vivo. Bioassay-guided fractionation of the methanolic extract resulted in isolation of suppressive compounds in the PCA test: methyleugenol (1), elemicin (2), gamma-asarone (3), (-)-asarinin (4), and (-)-sesamin (5). Furthermore, elemicin (2) and (2E,4E,8Z,10E)-N-isobutyl-2,4,8,10-dodecatetraenami de (6) were found to exhibit an inhibitory action on 5-lipoxygenase (5-LOX) from RBL-1 cells. 3',4'-Dimethoxycinnamaldehyde (7) and xanthoxylol (8) potently reduced the contractile response of guinea pig ileal strips to LTD4."\\
+"The methanolic extract of the roots of Asiasarum sieboldi has been evaluated for anti-allergic effects on various experimental models in vitro and in vivo. Bioassay-guided fractionation of the methanolic extract resulted in isolation of suppressive compounds in the PCA test: methyleugenol (1), elemicin (2), gamma-asarone (3), (-)-asarinin (4), and (-)-sesamin (5). Furthermore, elemicin (2) and (2E,4E,8Z,10E)-N-isobutyl-2,4,8,10-dodecatetraenamide (6) were found to exhibit an inhibitory action on 5-lipoxygenase (5-LOX) from RBL-1 cells. 3',4'-Dimethoxycinnamaldehyde (7) and xanthoxylol (8) potently reduced the contractile response of guinea pig ileal strips to LTD4."\\
 [Studies on anti-allergic components in the roots of Asiasarum sieboldi., Hashimoto, K., Yanagisawa, T., Okui, Y., Ikeya, Y., Maruno, M., Fujita, T., Planta medica, 60(2), 1994, 124-127]
-The amounts of aristolochic acids I and II (associated with a high incidence of uroepithelial tumorigenesis) in four groups of medicinal plants from the Aristolochiaceae and some related plants were determined by some researchers. Differnet amounts of them were found in Asarum heterotropoides var. mandshuricum, Asarum sieboldii (Usuba-saishin), Asarum heterotropoides (Keirin–saishin), Asarum sieboldii var. seoulense (Usuge-saishin) and commercial `Saishin' Asarum sect. Asiasarum sp. (Korean market), ranging from none to troubling 142 µg/g. \\
+The amounts of [[https://en.wikipedia.org/wiki/Aristolochic_acid|aristolochic acid I]] and II (associated with a high incidence of uroepithelial tumorigenesis) in four groups of medicinal plants from the Aristolochiaceae and some related plants were determined by some researchers. Differnet amounts of them were found in Asarum heterotropoides var. mandshuricum, Asarum sieboldii (Usuba-saishin), Asarum heterotropoides (Keirin–saishin), Asarum sieboldii var. seoulense (Usuge-saishin) and commercial `Saishin' Asarum sect. Asiasarum sp. (Korean market), ranging from none to troubling 142 µg/g. \\
 [Quantitative analysis of aristolochic acids, toxic compounds, contained in some medicinal plants., Hashimoto, K., Higuchi, M., Makino, B., Sakakibara, I., Kubo, M., Komatsu, Y., Okada, M., Journal of ethnopharmacology, 64(2), 1999, 185-189] \\
 [Determination of aristolochic acid A in Radix Aristolociae and Herba Asari by RP-HPLC., Jiang, X., Wang, Z.M., You, L.S., Dai, L.P., Ding, G.Z., Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi= China journal of Chinese materia medica, 29(5), 2004, 408-410] \\

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