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--- asarum_heterotropoides_f._schmidt [2015/07/02 07:50]
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+++ asarum_heterotropoides_f._schmidt [2015/07/02 07:56] (aktuell)
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 Two lignanes, asarinin and xanthoxylol, were isolated and exhidited  antitumor effects in mice. \\
 [Takasaki M, Konoshima T, Yasuda I, Hamano T, Tokuda H, Biol.Pharm.Bull., 20(7), 1997, 776-780]
-The amounts of toxic aristolochic acids I and II in four groups of medicinal plants from the Aristolochiaceae and some related plants were determined by high-pressure liquid chromatography, but Asarum sieboldii (Usuba-saishin), Asarum heterotropoides (Keirin–saishin), Asarum sieboldii var. seoulense (Usuge-saishin) and commercial `Saishin' Asarum sect. Asiasarum sp. (Korean market) contained none. \\
-[Quantitative analysis of aristolochic acids, toxic compounds, contained in some medicinal plants., Hashimoto, K., Higuchi, M., Makino, B., Sakakibara, I., Kubo, M., Komatsu, Y., Okada, M., Journal of ethnopharmacology, 64(2), 1999, 185-189]
 Root extracts (80% EtOH, LC) of A. heterotropoides contained tetrahydrofuran lignans, aristolactams, an aristolochic acid derivative, three flavanones, two monoterpenes, and four phenolics. Among the 22 tested compounds, two (7-methoxyaristololactam IV, and (7α,7'β,8α,8'α)-3,4-methylenedioxy-3',4'-dihydroxy-7,9':7',9-diepoxy-lignane) induced the downregulation of NO production, FOXP3 expression, and HIF-1α transcriptional activity. \\

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