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angelica_dahurica_fisch.ex_hoffm [2015/12/28 17:46]
andreas |
angelica_dahurica_fisch.ex_hoffm [2015/12/28 19:43]
andreas |
| "Angelica dahurica Bentham et Hooker ethanolic extract (ADEE)... inhibited cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, leading to the suppression of COX-2-derived prostaglandin E2 and iNOS-derived production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. These inhibitory effects of ADEE were accompanied by the reduced production of tumor necrosis factor α and interleukin (IL)-6. ADEE also inhibited nuclear factor κB (NFκB) translocation to the nucleus by interrupting inhibitor kappa Bα (IκBα) degradation. ADEE upregulated heme oxygenase 1 expression, and treatment with tin protoporphyrin IX (SnPP), a selective inhibitor of HO-1, reversed the LPS-induced generation of proinflammatory cytokines. ADEE also induced IL-4 and IL-5 expression in concanavalin-A-stimulated splenocytes. These results suggest that ADEE has anti-inflammatory activity, which acts via the suppression of the NF-κB pathway." \\ | "Angelica dahurica Bentham et Hooker ethanolic extract (ADEE)... inhibited cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, leading to the suppression of COX-2-derived prostaglandin E2 and iNOS-derived production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. These inhibitory effects of ADEE were accompanied by the reduced production of tumor necrosis factor α and interleukin (IL)-6. ADEE also inhibited nuclear factor κB (NFκB) translocation to the nucleus by interrupting inhibitor kappa Bα (IκBα) degradation. ADEE upregulated heme oxygenase 1 expression, and treatment with tin protoporphyrin IX (SnPP), a selective inhibitor of HO-1, reversed the LPS-induced generation of proinflammatory cytokines. ADEE also induced IL-4 and IL-5 expression in concanavalin-A-stimulated splenocytes. These results suggest that ADEE has anti-inflammatory activity, which acts via the suppression of the NF-κB pathway." \\ |
| [Anti-inflammatory activity of< i> Angelica dahurica</i> ethanolic extract on RAW264. 7 cells via upregulation of heme oxygenase-1. Lee, M. Y., Lee, J. A., Seo, C. S., Ha, H., Lee, H., Son, J. K., Shin, H. K., Food and Chemical Toxicology, Vol.49(5), 2011, 1047-1055] | [Anti-inflammatory activity of< i> Angelica dahurica</i> ethanolic extract on RAW264. 7 cells via upregulation of heme oxygenase-1. Lee, M. Y., Lee, J. A., Seo, C. S., Ha, H., Lee, H., Son, J. K., Shin, H. K., Food and Chemical Toxicology, Vol.49(5), 2011, 1047-1055] |
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| | {{:imperatorin.jpg| imperatorin }} [[https://en.wikipedia.org/wiki/Imperatorin|imperatorin]] |
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| "In total 50 coumarins, including 32 linear furanocoumarins, 16 bifuranocoumarins and two non-furanocoumarins, were identified from the roots of A. dahurica." "...a traditional Chinese medicine that used for the treatment of headache, toothache, abscess, furunculosis and acne." \\ | "In total 50 coumarins, including 32 linear furanocoumarins, 16 bifuranocoumarins and two non-furanocoumarins, were identified from the roots of A. dahurica." "...a traditional Chinese medicine that used for the treatment of headache, toothache, abscess, furunculosis and acne." \\ |
| [Simultaneous Characterisation of Fifty Coumarins from the Roots of Angelica dahurica by Off‐line Two‐dimensional High‐performance Liquid Chromatography Coupled with Electrospray Ionisation Tandem Mass Spectrometry. Li, B., Zhang, X., Wang, J., Zhang, L., Gao, B., Shi, S., Tu, P., Phytochemical Analysis, Vol.25(3), 2014, 229-240] | [Simultaneous Characterisation of Fifty Coumarins from the Roots of Angelica dahurica by Off‐line Two‐dimensional High‐performance Liquid Chromatography Coupled with Electrospray Ionisation Tandem Mass Spectrometry. Li, B., Zhang, X., Wang, J., Zhang, L., Gao, B., Shi, S., Tu, P., Phytochemical Analysis, Vol.25(3), 2014, 229-240] |
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