| Beide Seiten der vorigen Revision
Vorhergehende Überarbeitung
|
|
allium_ursinum_l [2016/05/16 11:05]
andreas |
allium_ursinum_l [2017/03/18 13:16] (aktuell)
andreas |
| Both A. ursinum and A. sativum exert antiaggregatory effects. Garlic extracts are acting by inhibition of the ADP pathway; their mechanisms of action are comparable to that of the clinically used drug clopidogrel. The pharmacologically active component of the extracts appears to be lipophilic rather than hydrophilic, but the precise chemical substance is still unknown. This is the first report on the antiplatelet activity of A. ursinum." \\ | Both A. ursinum and A. sativum exert antiaggregatory effects. Garlic extracts are acting by inhibition of the ADP pathway; their mechanisms of action are comparable to that of the clinically used drug clopidogrel. The pharmacologically active component of the extracts appears to be lipophilic rather than hydrophilic, but the precise chemical substance is still unknown. This is the first report on the antiplatelet activity of A. ursinum." \\ |
| [Antiplatelet activity of Allium ursinum and Allium sativum., Hiyasat, B., Sabha, D., Grotzinger, K., Kempfert, J., Rauwald, J.W., Mohr, F.W., Dhein, S., Pharmacology, Vol.(83), 2009, 197-204] | [Antiplatelet activity of Allium ursinum and Allium sativum., Hiyasat, B., Sabha, D., Grotzinger, K., Kempfert, J., Rauwald, J.W., Mohr, F.W., Dhein, S., Pharmacology, Vol.(83), 2009, 197-204] |
| | |
| | {{:allicin.jpg|}} allicin |
| |
| "It has been estimated that cysteine sulfoxides ([[http://de.wikipedia.org/wiki/Alliin|alliin]]) and the non-volatile γ-glutamylcysteine peptides make up more than 82% of the total sulfur content of ramsons. The thiosulfinates, ajoenes - a degraded form of [[http://de.wikipedia.org/wiki/Allicin|allicin]] - vinyldithiins and sulfides, however, are not naturally occurring compounds. Thiosulfinates formed in Allium are degraded to various polysulfides and ajoenes which also exhibit different degrees of antimicrobial activity. The volatile sulfur compounds show more potent inhibitory effects towards fungi than bacteria. To some extent, they are degradation products from the naturally occurring cysteine sulfoxide, alliin. When the bulb of the ramson is crushed, minced, or otherwise processed, alliin is released from divisions and interacts with the enzyme alliinase in adjacent vacuoles. Hydrolysis and condensation of the reactive intermediate (allylsulfenic acid) forms allicin... \\ | "It has been estimated that cysteine sulfoxides ([[http://de.wikipedia.org/wiki/Alliin|alliin]]) and the non-volatile γ-glutamylcysteine peptides make up more than 82% of the total sulfur content of ramsons. The thiosulfinates, ajoenes - a degraded form of [[http://de.wikipedia.org/wiki/Allicin|allicin]] - vinyldithiins and sulfides, however, are not naturally occurring compounds. Thiosulfinates formed in Allium are degraded to various polysulfides and ajoenes which also exhibit different degrees of antimicrobial activity. The volatile sulfur compounds show more potent inhibitory effects towards fungi than bacteria. To some extent, they are degradation products from the naturally occurring cysteine sulfoxide, alliin. When the bulb of the ramson is crushed, minced, or otherwise processed, alliin is released from divisions and interacts with the enzyme alliinase in adjacent vacuoles. Hydrolysis and condensation of the reactive intermediate (allylsulfenic acid) forms allicin... \\ |
