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akebia_quinata_houtt._decne [2015/03/20 15:38]
andreas
akebia_quinata_houtt._decne [2015/06/13 11:36] (aktuell)
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 [[https://​de.wikipedia.org/​wiki/​Fingerbl%C3%A4ttrige_Akebie]] [[https://​de.wikipedia.org/​wiki/​Fingerbl%C3%A4ttrige_Akebie]]
  
-Dried parts (cutted crosswise in traditional manner) of the stem is known as Akebiae caulis (Japanese Pharmacopoeia). Said to act diuretic, antipyretic,​ antinociceptive,​ stimulating on ileus. Several triterpenoid saponins were isolated from A.quinata containing hederagenin and oleanolic acid as triterpene aglycon. \\ +Dried parts (cutted crosswise in traditional manner) of the stem is known as Akebiae caulis (Japanese Pharmacopoeia). Said to act diuretic, antipyretic,​ antinociceptive,​ stimulating on ileus. Several triterpenoid saponins ​('​akebosides'​) ​were isolated from A.quinata containing hederagenin and oleanolic acid as triterpene aglycon. \\ 
-[Hagers Handbuch der Pharmazeutischen Praxis, Springer 2010]+[Hagers Handbuch der Pharmazeutischen Praxis, Springer 2010] \\ 
 +[The Study on the Constituents of Clematis and Akebia sp. III. The Study on the structures of Akebosides isolated from the Stem of Akebia quinata DECNE., 粂川芳広,​ 糸川秀治,​ & 藤田路一, ​ Chemical & pharmaceutical bulletin, Vol.22(10), 1974, 2294-2300]
  
 "The antinociceptive effect was tested by hot plate-writhing and tail-flicks methods using mice, and the anti-inflammatory effect was assayed using carrageenan-induced rat edema against the following samples: the MeOH extract of A. quinata stems, its fractions, the isolated saponin, kalopanaxsaponin A, and the sapogenins hederagenin and oleanolic acid. The MeOH extract exhibited antinociceptive/​anti-inflammatory effects by oral administration of 100 and 250 mg/kg doses, indicating that the MeOH extract has an antinociceptive/​anti-inflammatory activity. The BuOH fraction (crude saponin) also significantly exhibited those bioactivities. Treatments with 10 and 30 mg/kg perorally of these two sapogenins produced significant antinociceptive/​ anti-inflammatory effects in the rat, suggesting that the sapogenins may act as resultant active compounds. Compounds 2 and 3 inhibited dye leakage into the peritoneal cavity induced by acetic acid, and the latter was more active than the former. The anti-inflammtory effects were further supported by the reduction of carrageenan-induced lipid peroxidation and hydroxy radical content in serum. These results suggest that the antinociceptive/​anti-inflammatory properties of the stem of A. quinata can be attributed to the sapogenins oleanolic acid and hederagenin."​ \\ "The antinociceptive effect was tested by hot plate-writhing and tail-flicks methods using mice, and the anti-inflammatory effect was assayed using carrageenan-induced rat edema against the following samples: the MeOH extract of A. quinata stems, its fractions, the isolated saponin, kalopanaxsaponin A, and the sapogenins hederagenin and oleanolic acid. The MeOH extract exhibited antinociceptive/​anti-inflammatory effects by oral administration of 100 and 250 mg/kg doses, indicating that the MeOH extract has an antinociceptive/​anti-inflammatory activity. The BuOH fraction (crude saponin) also significantly exhibited those bioactivities. Treatments with 10 and 30 mg/kg perorally of these two sapogenins produced significant antinociceptive/​ anti-inflammatory effects in the rat, suggesting that the sapogenins may act as resultant active compounds. Compounds 2 and 3 inhibited dye leakage into the peritoneal cavity induced by acetic acid, and the latter was more active than the former. The anti-inflammtory effects were further supported by the reduction of carrageenan-induced lipid peroxidation and hydroxy radical content in serum. These results suggest that the antinociceptive/​anti-inflammatory properties of the stem of A. quinata can be attributed to the sapogenins oleanolic acid and hederagenin."​ \\
akebia_quinata_houtt._decne.txt · Zuletzt geändert: 2015/06/13 11:36 (Externe Bearbeitung)