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akebia_quinata_houtt._decne [2015/03/20 15:38]
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akebia_quinata_houtt._decne [2015/03/20 15:44]
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| [[https://de.wikipedia.org/wiki/Fingerbl%C3%A4ttrige_Akebie]] | [[https://de.wikipedia.org/wiki/Fingerbl%C3%A4ttrige_Akebie]] |
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| Dried parts (cutted crosswise in traditional manner) of the stem is known as Akebiae caulis (Japanese Pharmacopoeia). Said to act diuretic, antipyretic, antinociceptive, stimulating on ileus. Several triterpenoid saponins were isolated from A.quinata containing hederagenin and oleanolic acid as triterpene aglycon. \\ | Dried parts (cutted crosswise in traditional manner) of the stem is known as Akebiae caulis (Japanese Pharmacopoeia). Said to act diuretic, antipyretic, antinociceptive, stimulating on ileus. Several triterpenoid saponins ('akebosides') were isolated from A.quinata containing hederagenin and oleanolic acid as triterpene aglycon. \\ |
| [Hagers Handbuch der Pharmazeutischen Praxis, Springer 2010] | [Hagers Handbuch der Pharmazeutischen Praxis, Springer 2010] \\ |
| | [The Study on the Constituents of Clematis and Akebia sp. III. The Study on the structures of Akebosides isolated from the Stem of Akebia quinata DECNE., 粂川芳広, 糸川秀治, & 藤田路一, Chemical & pharmaceutical bulletin, Vol.22(10), 1974, 2294-2300] |
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| "The antinociceptive effect was tested by hot plate-writhing and tail-flicks methods using mice, and the anti-inflammatory effect was assayed using carrageenan-induced rat edema against the following samples: the MeOH extract of A. quinata stems, its fractions, the isolated saponin, kalopanaxsaponin A, and the sapogenins hederagenin and oleanolic acid. The MeOH extract exhibited antinociceptive/anti-inflammatory effects by oral administration of 100 and 250 mg/kg doses, indicating that the MeOH extract has an antinociceptive/anti-inflammatory activity. The BuOH fraction (crude saponin) also significantly exhibited those bioactivities. Treatments with 10 and 30 mg/kg perorally of these two sapogenins produced significant antinociceptive/ anti-inflammatory effects in the rat, suggesting that the sapogenins may act as resultant active compounds. Compounds 2 and 3 inhibited dye leakage into the peritoneal cavity induced by acetic acid, and the latter was more active than the former. The anti-inflammtory effects were further supported by the reduction of carrageenan-induced lipid peroxidation and hydroxy radical content in serum. These results suggest that the antinociceptive/anti-inflammatory properties of the stem of A. quinata can be attributed to the sapogenins oleanolic acid and hederagenin." \\ | "The antinociceptive effect was tested by hot plate-writhing and tail-flicks methods using mice, and the anti-inflammatory effect was assayed using carrageenan-induced rat edema against the following samples: the MeOH extract of A. quinata stems, its fractions, the isolated saponin, kalopanaxsaponin A, and the sapogenins hederagenin and oleanolic acid. The MeOH extract exhibited antinociceptive/anti-inflammatory effects by oral administration of 100 and 250 mg/kg doses, indicating that the MeOH extract has an antinociceptive/anti-inflammatory activity. The BuOH fraction (crude saponin) also significantly exhibited those bioactivities. Treatments with 10 and 30 mg/kg perorally of these two sapogenins produced significant antinociceptive/ anti-inflammatory effects in the rat, suggesting that the sapogenins may act as resultant active compounds. Compounds 2 and 3 inhibited dye leakage into the peritoneal cavity induced by acetic acid, and the latter was more active than the former. The anti-inflammtory effects were further supported by the reduction of carrageenan-induced lipid peroxidation and hydroxy radical content in serum. These results suggest that the antinociceptive/anti-inflammatory properties of the stem of A. quinata can be attributed to the sapogenins oleanolic acid and hederagenin." \\ |
