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- | Actaea racemosa L. - syn.Cimicifuga racemosa (L.) Nutt. - Ranunculaceae \\ | ||
- | black cohosh, black snakeroot, rattle weed, rattlesnake root, squawroot, **Traubensilberkerze**, | ||
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- | Perennial herb, up to 2.50m tall, native to eastern and central North America; leaves odd pinnate, serrate; flowers white, in racemes; fruit a black follicle, leathery, ovate, 5-10mm long. \\ | ||
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- | "Some phytoestrogens are believed to have selective estrogen receptor modulator (SERM) activity with no action in the uterus but beneficial effects in the hypothalamo/ | ||
- | (CR) extract BNO 1055 in the uterus, in the bone and on serum luteinizing hormone (LH) were compared with the effects of estradiol-17b(E2) under acute and chronic conditions in ovariectomized rats...When given acutely, both E2 and the CR extract inhibited LH secretion and slightly stimulated gene expression of IGF-I, collagen-1 | ||
- | a 1, osteoprotegerin and osteocalcin (all osteoblast products), and of tartrate-resistant acid phosphatase (TRAP, an osteoclast product) in the metaphysis of the femur. While E2 stimulated uterine weight and expression of progesterone receptor (PR), the complement protein (C3) and IGF-I genes, and inhibited gene expression of the estrogen receptor b (ERb) in the uterus, no such effect was observed under acute CR treatment. After chronic application with pelleted food over 3 months E2 had profound effects in the uterus on weight and gene expression (ERb, PR, C3 and IGF-I) which were not seen in the CR-treated animals. Within 3 months after ovariectomy, | ||
- | [Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta., | ||
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- | "One new triterpene glycoside, cimiracemoside, | ||
- | [Triterpenoid glycoside from Cimicifuga racemosa., Lai, G. F., Wang, Y. F., Fan, L. M., Cao, J. X., Luo, S. D., Journal of Asian natural products research, Vol.7(5), 2005, 695-699] | ||
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- | "Black cohosh (Cimicifuga racemosa) is an herbal supplement that is sold over-the-counter for management of menopausal symptoms, menstrual irregularities, | ||
- | [Guzman, G., Kallwitz, E. R., Wojewoda, C., Chennuri, R., Berkes, J., Layden, T. J., Cotler, S. J. (2010). Liver injury with features mimicking autoimmune hepatitis following the use of black cohosh. Case reports in medicine, 2009] | ||