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Angelica gigas Nakai - Apiaceae - 朝鲜当归 chao xian dang gui (chin.), Korean Angelica, **Koreanische Engelwurz**

Perennial herb, 1-2m tall, native to Korea, Japan and China; root conic, gray brown, 2-5 cm thick; stem purplish, ribbed; upper leaves purple-green; flowers dark purple-red. \\
[[http://www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=200015368]]

"Angelica gigas is an herb used in traditional Korean medicine, usually by women. It is being studied for its potential anti-cancer and immune-boosting properties." [[http://examine.com/supplements/Angelica+gigas/]]

"Korean traditional herbal medicine, Cham-Dang-Gui (Korean Angelica, the dried root of A. gigas Nakai), has
been widely used in the treatment of dysmenorrhea, amenorrhea, menopausal syndromes, anemia, abdominal pain, injuries, migraine headaches and arthritis. It is also known that this herbal medicine ensures healthy pregnancies and easy deliveries, and that coumarins such as decursin and decursinol angelate are the major constituents of this plant... \\
An high performance liquid chromatography-diode array detector coupled with electrospray ionization/mass spectrometry (HPLC-DAD/MS) based method has been developed for the simultaneous determination of nine coumarin compounds, nodakenin, peucedanone, marmesin, decursinol, 7-hydroxy-6-(2R-hydroxy-3-methylbut-3-enyl)coumarin, demethylsuberosin, decursin, decursinol angelate and isoimperatorin in the Korean medicinal herb, Cham-Dang-Gui, the dried root of Angelica gigas (Umbelliferae) [methanol extracts]." \\
[The simultaneous determination of coumarins in //Angelica gigas// root by high performance liquid chromatography–diode array detector coupled with electrospray ionization/mass spectrometry. Ahn, M. J., Lee, M. K., Kim, Y. C., Sung, S. H., Journal of pharmaceutical and biomedical analysis, Vol.46(2), 2008, 258-266] [[http://www.snupharm.ac.kr/shsung/erp/erpmenus/professor_thesis/upLoadFiles/5.pdf]]

"Decursin is considered the major bioactive compound of Angelica gigas roots, a popular Oriental herb and dietary supplement. In this study, the pharmacokinetics of decursin and its active metabolite, decursinol, were evaluated after the administration of decursin in rats... Interestingly, after oral administration of decursin, only decursinol was present in plasma, suggesting an extensive hepatic first-pass metabolism of decursin. The extremely low bioavailability of decursin after its administration via the hepatic portal vein (the fraction of dose escaping first-pass elimination in the liver, FH = 0.11) is indicative of extensive hepatic first-pass metabolism of decursin, which was confirmed by a tissue distribution study. These findings suggest that decursin is not directly associated with the bioactivity of A. gigas and that it may work as a type of natural prodrug of decursinol." \\
[First-pass Metabolism of Decursin, a Bioactive Compound of //Angelica gigas//, in Rats. Park, H. S., Kim, B., Oh, J. H., Kim, Y. C., Lee, Y. J., Planta medica, 78(09), 2012, 909-913]


{{:angelica_gigas.jpg?600}} \\
Flowers of Angelica gigas, Paul Henjum (2007) (PD, [[https://creativecommons.org/publicdomain/zero/1.0/deed.de|CC0]]) \\
[[https://en.wikipedia.org/wiki/Angelica_gigas#/media/File:Angelicagigas.jpg]]