| Beide Seiten der vorigen RevisionVorhergehende Überarbeitung | |
| salvia_miltiorrhiza_bunge [2015/08/01 09:48] – andreas | salvia_miltiorrhiza_bunge [2015/12/29 11:39] (aktuell) – andreas |
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| "Danshen (Radix Salviae Miltiorrhizae, SM) is a popular traditional Chinese herb widely used in treating cardiovascular, renal, and hepatic diseases by improving circulation and resolving stasis. [[http://pubchem.ncbi.nlm.nih.gov/compound/11629084|Salvianolic acid B]] (Sal B), also known as lithospermates B or tanshinoate B, is a major water soluble component extracted from SM, which was well recognized as an antioxidative agent and free radical scavenger, involved in the protection of various cells, including nerve cells and hepatocytes. It was reported that SM and its aqueous extract, Sal B, produced a good effect in treating patients and animals with chronic renal diseases... Sal B can prevent tubular EMT [epithelial-to-mesenchymal transition] in the fibrotic kidney... the mechanism of Sal B is closely related to the regulation of TGF-β1/Smads pathway, manifested as the inhibition of TGF-β1 expression, suppression of TβR-I expression and function, down-regulation of Smad2/3 phosphorylation, and restoration of the down-regulation of Smad7, as well as inhibition of MMP-2 activity." \\ | "Danshen (Radix Salviae Miltiorrhizae, SM) is a popular traditional Chinese herb widely used in treating cardiovascular, renal, and hepatic diseases by improving circulation and resolving stasis. [[http://pubchem.ncbi.nlm.nih.gov/compound/11629084|Salvianolic acid B]] (Sal B), also known as lithospermates B or tanshinoate B, is a major water soluble component extracted from SM, which was well recognized as an antioxidative agent and free radical scavenger, involved in the protection of various cells, including nerve cells and hepatocytes. It was reported that SM and its aqueous extract, Sal B, produced a good effect in treating patients and animals with chronic renal diseases... Sal B can prevent tubular EMT [epithelial-to-mesenchymal transition] in the fibrotic kidney... the mechanism of Sal B is closely related to the regulation of TGF-β1/Smads pathway, manifested as the inhibition of TGF-β1 expression, suppression of TβR-I expression and function, down-regulation of Smad2/3 phosphorylation, and restoration of the down-regulation of Smad7, as well as inhibition of MMP-2 activity." \\ |
| [Salvianolic acid B prevents epithelial-to-mesenchymal transition through the TGF-β1 signal transduction pathway in vivo and in vitro., Wang, Q.L., Tao, Y.Y., Yuan, J.L., Shen, L., Liu, C.H., BMC cell biology, 11(1), 2010, 31] [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874764/]] | [Salvianolic acid B prevents epithelial-to-mesenchymal transition through the TGF-β1 signal transduction pathway in vivo and in vitro., Wang, Q.L., Tao, Y.Y., Yuan, J.L., Shen, L., Liu, C.H., BMC cell biology, 11(1), 2010, 31] [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874764/]] |
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| | Danshen (Salviae miltiorrhizae radix et rhizoma) is used to treat menstrual disorders, abdominal pain, myoma, ulcers and carbuncles, restlessness, sleeping disorders, palpitation and chest pain. It should contain (PhEur 7.7): min. 0.12% tanshinone IIA and min. 3.0% salvianolic acid B, (PhPRC 2010): min. 0.20% tanshinone IIA and min. 3.0% salvianolic acid B. \\ |
| | [[http://www.lfl.bayern.de/mam/cms07/publikationen/daten/merkblaetter/chinese_medicinal_plants__cultivated_bavaria_lfl-merkblatt.pdf]] |
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| Tanshinone IIA was identified as a natural Monoacylglycerol lipase (MAGL) inhibitor in a concentration dependent manner (IC50 = 48 μM). "Considering being used as long-term treatment of cardiovascular diseases in China, tanshinone IIA has the potential to be developed as a good candidate for the treatment of Alzheimer's disease and other MAGL-associated diseases." \\ | Tanshinone IIA was identified as a natural Monoacylglycerol lipase (MAGL) inhibitor in a concentration dependent manner (IC50 = 48 μM). "Considering being used as long-term treatment of cardiovascular diseases in China, tanshinone IIA has the potential to be developed as a good candidate for the treatment of Alzheimer's disease and other MAGL-associated diseases." \\ |
| [Identification of tanshinone IIA as a natural monoacylglycerol lipase inhibitor by combined in silico and in vitro approach., Yang, R., Lu, Y., Liu, J., MedChemComm, 5(10), 2014, 1528-1532] | [Identification of tanshinone IIA as a natural monoacylglycerol lipase inhibitor by combined in silico and in vitro approach., Yang, R., Lu, Y., Liu, J., MedChemComm, 5(10), 2014, 1528-1532] |
