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--- polygala_senega_l [2015/06/03 06:18] – andreas
+++ polygala_senega_l [2015/06/13 09:39] (aktuell) – Externe Bearbeitung 127.0.0.1
@@ Zeile 8: / Zeile 8: @@
 [[http://www.henriettes-herb.com/eclectic/madaus/polygala-sene.html]]
-The root of P.senega displays immunopotentiation activity to protein and viral antigens. After hemolytic activity-guided fractionation, two dominant fractions were tested for adjuvant activity in mice immunized with ovalbumin, and hens immunized with rotavirus. The P. senega saponins increased specific antibody levels to the antigens, in both mice (IG2a) and hens. Upon in vitro secondary antigen stimulation, high IL-2 and IFN-γ levels were observed in spleen cell cultures from P. senega saponins-immunized animals. The saponins were less toxic at the same dose than their counterpart Quil A. "The results of this study indicated the potential of P. senega saponins as vaccine adjuvants to increase specific immune responses." \\
+The root of P.senega displays immunopotentiation activity to protein and viral antigens. After hemolytic activity-guided fractionation, two dominant fractions were tested for adjuvant activity in mice immunized with ovalbumin, and hens immunized with rotavirus. The P. senega saponins increased specific antibody levels to the antigens, in both mice (IG2a) and hens. Upon in vitro secondary antigen stimulation, high IL-2 and IFN-γ levels were observed in spleen cell cultures from P. senega saponins-immunized animals. The saponins were less toxic at the same dose than their counterpart Quil A, they are possible vaccine adjuvants to increase specific immune responses. \\
-[Isolation and evaluation of immunological adjuvant activities of saponins from Polygala senega L., Estrada, A., Katselis, G. S., Laarveld, B., Barl, B., Comparative immunology, microbiology and infectious diseases, Vol.23(1), 2000, 27-43]
+[Isolation and evaluation of immunological adjuvant activities of saponins from Polygala senega L., Estrada, A., Katselis, G. S., Laarveld, B., Barl, B., Comparative immunology, microbiology and infectious diseases, Vol.23(1), 2000, 27-43] \\
+[Adjuvant activities of saponins from the root of Polygala senega L., Katselis, G.S., Estrada, A., Gorecki, D.K., Barl, B., Canadian journal of physiology and pharmacology, Vol.85(11), 2007, 1184-1194]
 {{:polygala_senega.jpg?500}} \\
 Hamilton,E., Flora homoeopathica, Vol.2, t.58 (1853) \\
 [[http://plantgenera.org/species.php?id_species=821266]]