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--- peucedanum_ostruthium_l._koch [2015/02/26 11:21] – andreas
+++ peucedanum_ostruthium_l._koch [2015/06/13 09:39] (aktuell) – Externe Bearbeitung 127.0.0.1
@@ Zeile 2: / Zeile 2: @@
 masterwort, hogfennel, **Meisterwurz**, Kaiserwurz
-Perenniel herb, up to 80cm high;  rhizome creeping; leaves mainly basal; flowers white, occasionally slightly pink. \\
+Perenniel herb, up to 80cm high, native to the mountains of Central and Southern Europe; rhizome creeping; leaves mainly basal; flowers white, occasionally slightly pink. \\
 [[http://www.floranordica.org/Review/-Review_public/accounts/Peucedanum.html#Peucostr]]
+Especially the rhizomes of P.ostruthium (Radix magistralis) are traditionally used as ingredient of liqueurs and bitters. The dried herb and the roots were used as folk medicine and regarded as diaphoretic, diuretic, stomachic, sedative; now mainly used as spice and stomachic. \\
-The dried herb and the roots were used as folk medicine. Regarded as diaphoretic, diuretic, stomachic, sedative, now mainly used as spice and stomachic. \\
 [Hagers Handbuch der Pharmazeutischen Praxis, Springer 2010]
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 "Essential oil from herb and rhizome of Peucedanum ostruthium (L.Koch.) ex DC underwent qualitative and quantitative analyses. The content of the oil obtained by hydrodistillation was 0.95% in the herb and 1.25% in the rhizome (per dry weight basis). \\
-Gas chroma tography (GC) with MS detection and flame ionisation detection showed that the oil from the //rhizome// contains 39 compounds, of which 29 were identified. Gas chromatography with flame ionisation detection in chiral columns against standard compounds showed the presence of enantiomers of some of the components of the oil. Compounds present in largest quantities are: sabinene (35.2%) of which (+) sabinene accounts for (96.54%) and 4-terpineol (26.6%) of which (+) 4-terpineol accounts for (65.8%). \\
+Gas chroma tography (GC) with MS detection and flame ionisation detection showed that the oil from the //rhizome// contains 39 compounds, of which 29 were identified. Gas chromatography with flame ionisation detection in chiral columns against standard compounds showed the presence of enantiomers of some of the components of the oil. Compounds present in largest quantities are: sabinene (35.2%) of which (+)sabinene accounts for (96.54%) and 4-terpineol (26.6%) of which (+)4-terpineol accounts for (65.8%). \\
-components were found in the //herb essential oil//, of which 39 compounds were identified. Compounds present in largest quantities were β-caryophyllene (16.1%) and α-humulene (15.8%). The content of sabinene in the herb oil was 4.7%. The following compounds were present in the herb oil only as enantiomers: (+)sabinene (4.7%), (-)limonene (4.4%), (-) β-pinene (0.4%). \\
+components were found in the //herb essential oil//, of which 39 compounds were identified. Compounds present in largest quantities were β-caryophyllene (16.1%) and α-humulene (15.8%). The content of sabinene in the herb oil was 4.7%. The following compounds were present in the herb oil only as enantiomers: (+)sabinene (4.7%), (-)limonene (4.4%), (-)β-pinene (0.4%). \\
 A coumarin (osthole) was detected in both essential oils (5.5% in herb oil and 5.1% in rhizome oil)." \\
 [Essential oil from herb and rhizome of Peucedanum ostruthium (L. Koch). ex DC., Cisowskia, D. W., Sawickaa, U., Mardarowiczb, M., Asztemborskac, M., Luczkiewizd, M., Z. Naturforsch, 2001, 930-932] \\
 [[http://zfn.mpdl.mpg.de/data/Reihe_C/56/ZNC-2001-56c-0930.pdf]]
+HPLC profiling of the CH2Cl2 extract led to the identification of seven coumarins as major constituents. "The total coumarin content in this CH2Cl2 extract was determined to be 78%, whereas the content per gram dry weight of plant material was 6%. [[http://pubchem.ncbi.nlm.nih.gov/substance/11472#section=Top|Ostruthin]] was quantified as the main coumarin (41% of the total coumarin content), followed by oxypeucedanin (18%), ostruthol (13%), imperatorin (12%), isoimperatorin (9%), oxypeucedanin hydrate (6%), and osthole (1%)." \\
+[Identification of Ostruthin from Peucedanum ostruthium Rhizomes as an inhibitor of vascular smooth muscle cell proliferation., Joa, H., Vogl, S., Atanasov, A. G., Zehl, M., Nakel, T., Fakhrudin, N., Dirsch, V. M., Journal of natural products, Vol.74(6), 2011, 1513-1516] \\
+[[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122331/]]
+{{:osthrutin.jpg|}} osthrutin
+Main coumarins of dichloromethane extracts of commercial P.ostruthium root samples were the linear furanocoumarins oxypeucedanin hydrate (2-7%), oxypeucedanin (17-20%), ostruthol (12-14%), imperatorin (12-15%), isoimperatorin (9-10%), and oxypeucedanin ethanolate and the simple coumarins osthole (1%) and ostruthin (38-41%). A chromone, peucenin, was identified by LC-MS only. \\
+[Identification and quantification of coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS., Vogl, S., Zehl, M., Picker, P., Urban, E., Wawrosch, C., Reznicek, G., Kopp, B., Journal of agricultural and food chemistry, Vol.59(9), 2011, 4371-4377]
 {{http://plantgenera.org/ILLUSTRATIONS_HD/152292.jpg?500}} \\