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matricaria_chamomilla_l [2018/06/25 13:24] andreasmatricaria_chamomilla_l [2025/05/18 14:59] (aktuell) andreas
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 The dark blue colored chamazulene is an artifact of the steam distillation of German chamomile flowers. The essential oil collected by steam distillation contained bisabololoxide A (57.6%), chamazulene (23.3%), bisabolonoxide A (4.1%), bisabololoxide B (4.3%), (E)-β-farnesene (2.9%), and germacrene D (1.4%). The fruit esters, ocimenes, artemisia keton and β-selinene were only found in traces. \\  The dark blue colored chamazulene is an artifact of the steam distillation of German chamomile flowers. The essential oil collected by steam distillation contained bisabololoxide A (57.6%), chamazulene (23.3%), bisabolonoxide A (4.1%), bisabololoxide B (4.3%), (E)-β-farnesene (2.9%), and germacrene D (1.4%). The fruit esters, ocimenes, artemisia keton and β-selinene were only found in traces. \\ 
 [Brunke E.-J., Hammerschmidt F.-J., Schmaus G., Flower scent of some traditional medicinal plants., in: Teranishi, R.;Buttery, R. G.;Sugisawa, H. Bioactive volatile compounds from plants. (Book) 1993, 282-296] [Brunke E.-J., Hammerschmidt F.-J., Schmaus G., Flower scent of some traditional medicinal plants., in: Teranishi, R.;Buttery, R. G.;Sugisawa, H. Bioactive volatile compounds from plants. (Book) 1993, 282-296]
 +
 +Extraction of the flowers (4kg) of M.chamomilla with hexane (80g extract) followed by column chromatography yielded mainly the [[https://www.thegoodscentscompany.com/data/rw1031831.html|balsamic sweet tonka-scented herniarin]] (1.76g), oleanolic acid,  stigmasterol, ß-sitosterol, and its glucoside. \\
 +[Ahmad, A., and L. N. Misra. "Isolation of herniarin and other constituents from Matricaria chamomilla flowers." International journal of pharmacognosy 35.2 (1997): 121-125] [[https://www.tandfonline.com/doi/pdf/10.1076/phbi.35.2.121.13280]]
  
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 [Pro-apoptotic activity of a-bisabolol in preclinical models of primary human acute leukemia cells., Cavalieri, E., Rigo, A., Bonifacio, M., de Prati, A.C., Guardalben, E., Bergamini, C., Vinante, F., J Transl Med, Vol.9, 2011, 45] \\ [Pro-apoptotic activity of a-bisabolol in preclinical models of primary human acute leukemia cells., Cavalieri, E., Rigo, A., Bonifacio, M., de Prati, A.C., Guardalben, E., Bergamini, C., Vinante, F., J Transl Med, Vol.9, 2011, 45] \\
 [[http://www.biomedcentral.com/content/pdf/1479-5876-9-45.pdf]] [[http://www.biomedcentral.com/content/pdf/1479-5876-9-45.pdf]]
 +
 +Main volatile compounds of dried chamomile flowers collected with headspace solid-phase microextraction (HS-SPME) were (E)-β-farnesene (49%), artemisia ketone (10.1%), germacrene D (9.1%) and sabinene (7.7%). Interesting minor components not present in the essential oil (steam distillation-solvent extract, SDSE) were e.g. methyl 2-methylbutanoate (0.3%), ethyl 2-methyl butyrate (1.6%), propyl 2-methylbutanoate (0.5%), benzaldehyde (0.5%), and 1,8-cineole (2.2%). Main components of the essential oil were α-bisabolol oxide A (48.0%), chamazulene (20.4%), (E)-β-darnesene (6.7%) and (Z)-spiroether (6.7%). \\
 +[Rafieiolhossaini, Mohammad, et al. "Fast quality assessment of German chamomile (Matricaria chamomilla L.) by headspace solid-phase microextraction: influence of flower development stage." Natural Product Communications 7.1 (2012): 1934578X1200700133.]
  
 In chamomile tea, "...at most only 16% of the genuine essential oil can be extracted by infusion. High amounts of spiro ethers [cis- and trans-enyne-dicycloether] (ca.30% in the infusion vs. ca. 12% in the genuine oil) and coumarins (7%) [namely methylumbelliferone 5.5%] and reduced amounts of bisabolol oxides (ca. 32% in the infusion vs. ca. 60% in the genuine oil) can be regarded as markers of the volatile fraction of chamomile tea." \\ In chamomile tea, "...at most only 16% of the genuine essential oil can be extracted by infusion. High amounts of spiro ethers [cis- and trans-enyne-dicycloether] (ca.30% in the infusion vs. ca. 12% in the genuine oil) and coumarins (7%) [namely methylumbelliferone 5.5%] and reduced amounts of bisabolol oxides (ca. 32% in the infusion vs. ca. 60% in the genuine oil) can be regarded as markers of the volatile fraction of chamomile tea." \\
matricaria_chamomilla_l.1529933063.txt.gz · Zuletzt geändert: 2018/06/25 13:24 von andreas

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