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--- sanguinaria_canadensis_l [2015/10/23 20:06]
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+++ sanguinaria_canadensis_l [2015/10/23 20:27]
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 [Sanguinarine: a positive inotropic alkaloid which inhibits cardiac Na+, K+-ATPase., Seifen, E., Adams, R.J., Riemer, R.K., European journal of pharmacology, 60(4), 1979, 373-377]
-"The sanguinaria regimen reduced plaque by 57%, gingival inflammation by 60%, and sulcular bleeding by 45% from baseline compared with placebo group reductions of 27% (plaque) and 21% (gingival inflammation), and an increase of 30% in bleeding index...  the combined use of the sanguinaria-containing toothpaste and oral rinse controls and reduces plaque and gingival inflammation in an orthodontic population." \\
+"A sanguinaria-containing toothpaste and oral rinse regimen was evaluated during a 6-month period to determine its effectiveness in controlling plaque, gingival inflammation, and sulcular bleeding... The sanguinaria regimen reduced plaque by 57%, gingival inflammation by 60%, and sulcular bleeding by 45% from baseline compared with placebo group reductions of 27% (plaque) and 21% (gingival inflammation), and an increase of 30% in bleeding index...  the combined use of the sanguinaria-containing toothpaste and oral rinse controls and reduces plaque and gingival inflammation in an orthodontic population." \\
 [Long-term clinical evaluation of toothpaste and oral rinse containing sanguinaria extract in controlling plaque, gingival inflammation, and sulcular bleeding during orthodontic treatment., Hannah, J.J., Johnson, J.D., Kuftinec, M.M., American Journal of Orthodontics and Dentofacial Orthopedics, 96(3), 1989, 199-207]
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 [In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis., Mahady, G.B., Pendland, S.L., Stoia, A., Chadwick, L.R., Phytotherapy Research, 17(3), 2003, 217-221]
-The dried rhizome, with roots removed (Sanguinariae canadensis rhizoma), is traditionally used (infusion) as an emetic, expectorant and spasmolytic to treat bronchitis, asthma, cough, croup, laryngitis and pharyngitis. Most common modern use is (as extract in mouth rinses and toothpaste) to conteract dental plaque and gingivitis. \\
+The dried rhizome, with roots removed (Sanguinariae canadensis rhizoma), is traditionally used (infusion) as an emetic, expectorant and spasmolytic to treat bronchitis, asthma, cough, croup, laryngitis and pharyngitis. Most common modern use is (as extract in mouth rinses and toothpaste) to conteract dental plaque and gingivitis. "Since sanguinarin and some of the other alkaloids can intercalate DNA, they are potential mutagens. There is new evidence that prolonged use in oral hygiene products may be harmful." \\
 [Medicinal Plants of the World. Ben-Erik Van Wyk and Michael Wink, Pretoria 2004, 286]

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