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--- sanguinaria_canadensis_l [2015/10/23 09:03]
andreas angelegt
+++ sanguinaria_canadensis_l [2015/10/23 15:57]
andreas
@@ Zeile 6: / Zeile 6: @@
 [[http://www.efloras.org/florataxon.aspx?flora_id=1&taxon_id=220011939]]
+"In isolated, isometrically contracting left guinea pig atria, sanguinarine, a benzophenanthridine alkaloid from the papaveracea Sanguinaria canadensis, produced a concentration-dependent positive inotropic effect. Between 2.3 × 10−6 M and 6.5 × 10−5 M, sanguinarine increased contractility by 108% which was comparable to the maximal inotropic effect of ouabain. Within the same concentration range, sanguinarine caused inhibition of Na+,K+-ATPase isolated from guinea pig myocardium. 100% inhibition of Na+,K+-ATPase activity occurred at 1 × 10−4 M sanguinarine. The I50 for enzyme inhibition and the ED50 for the inotropic action of sanguinarine were the same (6–6.5 × 10−6 M) indicating that both effects may be causally related." \\
+[Sanguinarine: a positive inotropic alkaloid which inhibits cardiac Na+, K+-ATPase., Seifen, E., Adams, R.J., Riemer, R.K., European journal of pharmacology, 60(4), 1979, 373-377]
+"The rhizome extracts, as well as a methanol extract of S. canadensis suspension-cell cultures inhibited the growth of H. pylori in vitro, with a MIC50 range of 12.5–50.0 µg/ml. Three isoquinoline alkaloids were identiﬁed in the active fraction. Sanguinarine and chelerythrine, two benzophenanthridine alkaloids, inhibited the growth of the bacterium, with an MIC50 of 50.0 and 100.0 µg/ml, respectively." \\
+[In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis., Mahady, G.B., Pendland, S.L., Stoia, A., Chadwick, L.R., Phytotherapy Research, 17(3), 20003, 217-221]
+Sanguinarine has recently been shown to exhibit potent anti-MRSA activity in vitro by disrupting the cytoplasmic membrane of MRSA. "The activity of sanguinarine against MRSA strains ranged from 3.12 to 6.25 µg/ml, while the minimum inhibitory concentrations of the two reference strains are 3.12 µg/ml and 1.56 µg/ml. The treatment of the cells with sanguinarine induced the release of membrane-bound cell wall autolytic enzymes, which eventually resulted in lysis of the cell." \\
+[The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus., Obiang-Obounou, B.W., Kang, O.H., Choi, J.G., Keum, J.H., Kim, S.B., Mun, S.H., Kwon, D.Y. The Journal of toxicological sciences, 36(3), 2011, 277-283]
+{{:sanguinaria_canadensis.jpg?500}} \\
+Millspaugh,C.F., American medicinal plants, vol.1, t.22 (1892) \\
+[[http://plantgenera.org/species.php?id_species=904722]]

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