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--- salvia_divinorum_epling_jativa [2015/08/01 12:59]
andreas
+++ salvia_divinorum_epling_jativa [2019/04/29 10:22]
andreas
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 "Salvia divinorum is used by the Mazatec Indians of northeastern Oaxaca, Mexico primarily for its psychoactive
 effects which aid in ritual divination (Wasson, 1962, 1963). It is also employed remedially to treat various  health conditions... Traditionally the herb is consumed either by chewing the fresh leaves or by drinking the juices of freshly crushed leaves. The effects of the herb when consumed this way depend on absorption of salvinorin A through the oral mucosa before the herb is swallowed... When salvinorin A is vaporized and inhaled the full effects are experienced in about 30 s. There is almost no transition period experienced. The
-strongest effects last 5-10 min and then gradually subside over about 20-30 min. As dosage increases above 1 mg the duration of the effects are somewhat increased. A similar evolution of effects is reported for smoked S. divinorum leaves... Certain themes are common to many of the visions and sensations described. The following is a listing of some of the more common themes: Becoming objects (yellow plaid French fries, fresh paint, a drawer, a pant leg, a Ferris wheel, etc.). Visions of various two dimensional surfaces, films and membranes. Revisiting places from the past, especially childhood. Loss of the body and/or identity. Various sensations of motion, or being pulled or twisted by forces of some kind. Uncontrollable hysterical laughter. Overlapping realities. The perception that one is in several locations at once." \\
+strongest effects last 5-10 min and then gradually subside over about 20-30 min. As dosage increases above 1 mg the duration of the effects are somewhat increased. A similar evolution of effects is reported for smoked S. divinorum leaves." \\
 [Salvia divinorum and salvinorin A: new pharmacologic findings., Siebert, D.J., Journal of ethnopharmacology, 43(1), 1994, 53-56] [[http://www.sagewisdom.org/siebertjep94.pdf]]
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 [Salvinorin A, an active component of the hallucinogenic sage Salvia divinorum is a highly efficacious κ-opioid receptor agonist: structural and functional considerations., Chavkin, C., Sud, S., Jin, W., Stewart, J., Zjawiony, J.K., Siebert, D.J., Roth, B.L., Journal of Pharmacology and Experimental Therapeutics, 308(3), 2004, 1197-1203]
+"Salvinorin-A, the main psychoactive constituent in S. divinorum, is a non-nitrogenous neoclerodane diterpene with an affinity for the kappa opioid receptor (KOR; Roth et al., 2002). Despite its intense perception-modifying effects in humans, in vitro studies have shown that salvinorin-A does not bind to 5HT2A receptors, the molecular target of classic psychedelics like lysergic acid diethylamide (LSD), mescaline, psilocybin, and dimethyltryptamine (Roth et al., 2002; Prisinzano, 2005). ... \\
+Salvinorin-A led to a disconnection from external reality, induced elaborate visions and auditory phenomena, and modified interoception. The lower doses increased somatic sensations, but the highest dose led to a sense of a complete loss of contact with the body." \\
+[Maqueda, Ana Elda, et al. "Salvinorin-A induces intense dissociative effects, blocking external sensory perception and modulating interoception and sense of body ownership in humans." International Journal of Neuropsychopharmacology 18.12 (2015): pyv065.] [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675976/]]

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