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pelargonium_sidoides_dc [2015/12/17 12:33]
andreas
pelargonium_sidoides_dc [2015/12/17 13:30]
andreas
Zeile 17: Zeile 17:
 The root extract (EPs® 7630) contained coumarins like [[https://pubchem.ncbi.nlm.nih.gov/compound/Umckalin#section=Top|umckalin]], 6,8-dihydroxy-5,7-dimethoxycumarin, 5-hydroxy-6,7-dimethoxycumarin-8-sulfate and polyphenols (polyphenol content of ca. 22%) like catechin/epicatechin, gallocatechin/epigallocatechin, gallocatechin-4α,8-epigallocatechin, epicatechin-4β,8-epigallocatechin, gallocatechin-4α,6-gallocatechin and epigallocatechin-4β,8-epicatechin as well as proanthocyanidins (prodelphinidins). \\ The root extract (EPs® 7630) contained coumarins like [[https://pubchem.ncbi.nlm.nih.gov/compound/Umckalin#section=Top|umckalin]], 6,8-dihydroxy-5,7-dimethoxycumarin, 5-hydroxy-6,7-dimethoxycumarin-8-sulfate and polyphenols (polyphenol content of ca. 22%) like catechin/epicatechin, gallocatechin/epigallocatechin, gallocatechin-4α,8-epigallocatechin, epicatechin-4β,8-epigallocatechin, gallocatechin-4α,6-gallocatechin and epigallocatechin-4β,8-epicatechin as well as proanthocyanidins (prodelphinidins). \\
 "EPs® 7630 respectively the contained proanthocyanidins reduce the adhesiveness of group A streptococci by up to 47% (at an incubation concentration of 30 µg/ml). Here, the trihydroxylation of the B ring of the flavan-3-ol-subunits is of crucial importance for the activity, while the degree of polymerization plays a subordinate role. \\ "EPs® 7630 respectively the contained proanthocyanidins reduce the adhesiveness of group A streptococci by up to 47% (at an incubation concentration of 30 µg/ml). Here, the trihydroxylation of the B ring of the flavan-3-ol-subunits is of crucial importance for the activity, while the degree of polymerization plays a subordinate role. \\
-EPs® 7630 has a remarkably high inhibitory activity against neuraminidase (IC50 ca. 1 uGu/ml). The commercially available drugs zanamivir (IC50 ca. 18 µg/ml) and oseltamivir carboxylate (IC50 ca. 54 µg/ml) are considerably less active in the used in vitro model. The enzyme is significantly inhibited by proanthocyanidins, with a minimum chain length of three subunits." \\+EPs® 7630 has a remarkably high inhibitory activity against neuraminidase (IC50 ca. 1 µ/ml). The commercially available drugs zanamivir (IC50 ca. 18 µg/ml) and oseltamivir carboxylate (IC50 ca. 54 µg/ml) are considerably less active in the used in vitro model. The enzyme is significantly inhibited by proanthocyanidins, with a minimum chain length of three subunits." \\
 [Beitrag zur Kenntnis der Inhaltsstoffe und der Wirkung des Pelargonium sidoides Spezialextraktes EPs® 7630., Janecki, A., (Doctoral dissertation, Freie Universität Berlin, Germany), 2013] [Beitrag zur Kenntnis der Inhaltsstoffe und der Wirkung des Pelargonium sidoides Spezialextraktes EPs® 7630., Janecki, A., (Doctoral dissertation, Freie Universität Berlin, Germany), 2013]
  
pelargonium_sidoides_dc.txt · Zuletzt geändert: 2017/08/31 12:12 von andreas