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justicia_adhatoda_l [2015/11/17 12:45]
andreas 		justicia_adhatoda_l [2015/11/17 12:57]
andreas
Zeile 9: Zeile 9:
 [Quantitative determination of vasicine and vasicinone in Adhatoda vasica [Quantitative determination of vasicine and vasicinone in Adhatoda vasica
 by high performance capillary electrophoresis. B. Avula, S. Begum, S. Ahmed, M. I. Choudhary, I.A.Khan, Pharmazie 63: 20-22 (2008)] by high performance capillary electrophoresis. B. Avula, S. Begum, S. Ahmed, M. I. Choudhary, I.A.Khan, Pharmazie 63: 20-22 (2008)]
 +
 +"... even at the highest clinically used doses ambroxol does not have significant direct effects on the CNS. At clinically relevant plasma concentrations ambroxol either does not penetrate blood-brain barrier, or its brain levels are too low to cause relevant effects. \\
 +Ambroxol has been used in the therapy of airway diseases since late 1970s. Its history can be traced, however, to ayurvedic medicine in ancient India. The plant Adhatoda vasica has been used in India for similar indications for centuries. In Germany this plant is still called ‘Indisches Lungenkraut’ (Indian lung weed). The likely active substance in the plant is the alkaloid, vasicine. A chemically related drug, bromhexine, was introduced in 1965 to treat mild respiratory disorders. Ambroxol, the active metabolite of bromexine, has been found to be responsible for the therapeutic effect; and found to be superior to bromhexine in its pharmacokinetics, efficacy, and side effect profile." \\
 +[Ambroxol: a CNS drug?., Weiser, T., CNS neuroscience & therapeutics, 14(1), 2008, 17-24] 
  
 "Adhatoda vasica has been used in many ayurvedic formulations... Remarkable wound healing activity was observed with the ointment formulation of the methanol extract at 1% concentration." \\ "Adhatoda vasica has been used in many ayurvedic formulations... Remarkable wound healing activity was observed with the ointment formulation of the methanol extract at 1% concentration." \\
Zeile 17: Zeile 21:
 whooping cough and chronic bronchitis and asthma, as sedative expectorant, antispasmodic and anthelmintic. It is an official drug and is mentioned in the Pharmacopoeia of India. The leaves, roots, flowers and bark of Adhatoda are all used for medicinal purposes. It is well known for preparation of medicine for bronchitis, asthma and other pulmonary infections." \\ whooping cough and chronic bronchitis and asthma, as sedative expectorant, antispasmodic and anthelmintic. It is an official drug and is mentioned in the Pharmacopoeia of India. The leaves, roots, flowers and bark of Adhatoda are all used for medicinal purposes. It is well known for preparation of medicine for bronchitis, asthma and other pulmonary infections." \\
 [Adhatoda vasica Nees: Phytochemical and Pharmacological Profile. Thokchom P Singh, Okram M Singh, Huidrom B Singh, The Natural Products Journal 01/2011; 1(29), 29-39] [Adhatoda vasica Nees: Phytochemical and Pharmacological Profile. Thokchom P Singh, Okram M Singh, Huidrom B Singh, The Natural Products Journal 01/2011; 1(29), 29-39]
- +[[http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2007.00032.x/full]]
justicia_adhatoda_l.txt · Zuletzt geändert: 2018/03/12 10:24 von andreas

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