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chelidonium_majus_l [2015/10/04 13:40]
andreas |
chelidonium_majus_l [2015/10/04 13:46]
andreas |
| "Two ethanolic dry extracts from the herb Chelidonium majus L. with a defined content of the main alkaloids (chelidonine, protopine, and coptisisine) and the alkaloids themselves were studied in three different antispasmodic test models on isolated ileum of guinea-pigs. In the BaCl2-stimulated ileum, chelidonine and protopine exhibited the known papaverine-like musculotropic action, whereas coptisine (up to 3.0 x 10(-5) g/ml) was ineffective in this model. Both extracts were active with 53.5% and 49.0% relaxation at 5 x 10(-4) g/ml. The carbachol and the electric field stimulated contractions were antagonized by all three alkaloids. Coptisine showed competitive antagonist behaviour with a pA2 value of 5.95. Chelidonine and protopine exhibited a certain degree of non-competitive antagonism. In the electric field the antagonist activities decreased in the order protopine > coptisine > chelidonine. The concentrations of the chelidonium herb extracts for 50% inhibition of the carbachol and electrical field induced spasms were in the range of 2.5 to 5 x 10(-4) g/ml." \\ | "Two ethanolic dry extracts from the herb Chelidonium majus L. with a defined content of the main alkaloids (chelidonine, protopine, and coptisisine) and the alkaloids themselves were studied in three different antispasmodic test models on isolated ileum of guinea-pigs. In the BaCl2-stimulated ileum, chelidonine and protopine exhibited the known papaverine-like musculotropic action, whereas coptisine (up to 3.0 x 10(-5) g/ml) was ineffective in this model. Both extracts were active with 53.5% and 49.0% relaxation at 5 x 10(-4) g/ml. The carbachol and the electric field stimulated contractions were antagonized by all three alkaloids. Coptisine showed competitive antagonist behaviour with a pA2 value of 5.95. Chelidonine and protopine exhibited a certain degree of non-competitive antagonism. In the electric field the antagonist activities decreased in the order protopine > coptisine > chelidonine. The concentrations of the chelidonium herb extracts for 50% inhibition of the carbachol and electrical field induced spasms were in the range of 2.5 to 5 x 10(-4) g/ml." \\ |
| [Antispasmodic and relaxant activity of chelidonine, protopine, coptisine, and Chelidonium majus extracts on isolated guinea-pig ileum., Hiller, K.O., Ghorbani, M., Schilcher, H., Planta medica, 64(8), 1998, 758-760] | [Antispasmodic and relaxant activity of chelidonine, protopine, coptisine, and Chelidonium majus extracts on isolated guinea-pig ileum., Hiller, K.O., Ghorbani, M., Schilcher, H., Planta medica, 64(8), 1998, 758-760] |
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| | "The characteristic latex also contains proteolytic enzymes and the phytocystatin chelidostatin, a cysteine protease inhibitor. These co-constituents could explain the topical use of greater celandine against warts and moles." [[http://en.wikipedia.org/wiki/Chelidonium_majus]] \\ |
| | [Chelidocystatin, a novel phytocystatin from Chelidonium majus., Rogelj, B., Popovič, T., Ritonja, A., Štrukelj, B., Brzin, J., Phytochemistry, 49(6), 1645-1649] |
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| Toxicity and pharmacological activity are discussed for several years. http://gjrmi.com/Upload/Apr2013/Biswas%20S%20J.,%20GJRMI%202%284%29_%20238-245.pdf \\ | Toxicity and pharmacological activity are discussed for several years. http://gjrmi.com/Upload/Apr2013/Biswas%20S%20J.,%20GJRMI%202%284%29_%20238-245.pdf \\ |
| There are many reports about the hepatotoxic action of Chelidonium extracts. http://www.aerzteblatt.de/pdf.asp?id=34606 | There are many reports about the hepatotoxic action of Chelidonium extracts. http://www.aerzteblatt.de/pdf.asp?id=34606 |
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| http://en.wikipedia.org/wiki/Chelidonium_majus | |
| http://de.wikipedia.org/wiki/Sch%C3%B6llkraut | |
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| {{:dsc01025k.jpg?800|}} | {{:dsc01025k.jpg?800|}} |
