| Beide Seiten der vorigen Revision
Vorhergehende Überarbeitung
|
Nächste Überarbeitung
Beide Seiten der Revision
|
carlina_acaulis_l [2015/09/12 13:41]
andreas |
carlina_acaulis_l [2015/09/12 13:42]
andreas |
| |
| Decoctions and essential oil of "Carlinae radix" are commonly used by the locals in Serbia for the treatment of respiratory and urogenital diseases and, externally, for various skin conditions. Chemical composition of a commercial Carlinae radix herbal drug sample pointed to Carlina acanthifolia L. (Asteraceae) instead of Carlina acaulis L. (Asteraceae). The essential oil of this sample obtained by hydrodistillation "... was screened for antimicrobial activity by disc diffusion and broth microdilution methods... Both the essential oil and the decocts exhibited a very high antimicrobial activity against all tested strains, with S.aureus as the most sensitive one..." \\ | Decoctions and essential oil of "Carlinae radix" are commonly used by the locals in Serbia for the treatment of respiratory and urogenital diseases and, externally, for various skin conditions. Chemical composition of a commercial Carlinae radix herbal drug sample pointed to Carlina acanthifolia L. (Asteraceae) instead of Carlina acaulis L. (Asteraceae). The essential oil of this sample obtained by hydrodistillation "... was screened for antimicrobial activity by disc diffusion and broth microdilution methods... Both the essential oil and the decocts exhibited a very high antimicrobial activity against all tested strains, with S.aureus as the most sensitive one..." \\ |
| [Stojanović-Radić, Z., Čomić, L., Radulović, N., Blagojević, P., Mihajilov-Krstev, T., & Rajković, J. (2012). Commercial Carlinae radix herbal drug: Botanical identity, chemical composition and antimicrobial properties. Pharmaceutical biology, 50(8), 933-940] | [Commercial Carlinae radix herbal drug: Botanical identity, chemical composition and antimicrobial properties., Stojanović-Radić, Z., Čomić, L., Radulović, N., Blagojević, P., Mihajilov-Krstev, T., Rajković, J., Pharmaceutical biology, 50(8), 2012, 933-940] |
| |
| "Obtained activities of Carlina herb extracts were in correlation with the presence of phenolic compounds identified in both extracts using HPLC. As previously shown, apigenin, luteolin and their glycosides are powerful antioxidants. Flavone C-glycosides (orientin, homoorientin, and vitexin) are capable of blocking chain reactions of lipid auto-oxidation, chelating metal ions of transient state, scavenging nitric compounds and blocking the synthetic reaction of nitrosamine. Orientin expresses strong radical scavenging activity and thus, high radioprotective efficacy. Some compounds identified in the investigated Carlina herb extracts demonstrated anti-inflammatory properties earlier. Apigenin has COX-2 inhibitory activity comparable to NSAIL. Vitexin and schaftoside inhibit LPS-induced mouse lung inflammation. Luteolin inhibits lipopolysaccharide-induced TNF-α production. Flavones resembling luteolin in structure (with 3',4',5,7-tetrahydroxy substitution) also resemble its anti-inflammatory activity. Isoorientin has been shown to possess significant anti-nociceptive and anti-inflammatory activities. Chlorogenic acid inhibits SE-induced T-cell proliferation and production of various pro-inflammatory compounds (e.g. IL-1β, TNF-α, IL-6, INF-γ, MCP-1, MIP-1α and MIP-1β) by human peripheral blood mononuclear cells and may serve as a potent anti-inflammatory agent. Antioxidant activity of the investigated extracts could be, at least partly, responsible for the observed anti-inflammatory effects, since it was earlier shown that antioxidants may mediate anti-inflammatory activity by direct scavenging of ROS, by influencing polymorphonuclear neutrophils oxidative metabolism and also by preventing induction of the cytokine cascade and up-regulating the expression of adhesion molecules " \\ | "Obtained activities of Carlina herb extracts were in correlation with the presence of phenolic compounds identified in both extracts using HPLC. As previously shown, apigenin, luteolin and their glycosides are powerful antioxidants. Flavone C-glycosides (orientin, homoorientin, and vitexin) are capable of blocking chain reactions of lipid auto-oxidation, chelating metal ions of transient state, scavenging nitric compounds and blocking the synthetic reaction of nitrosamine. Orientin expresses strong radical scavenging activity and thus, high radioprotective efficacy. Some compounds identified in the investigated Carlina herb extracts demonstrated anti-inflammatory properties earlier. Apigenin has COX-2 inhibitory activity comparable to NSAIL. Vitexin and schaftoside inhibit LPS-induced mouse lung inflammation. Luteolin inhibits lipopolysaccharide-induced TNF-α production. Flavones resembling luteolin in structure (with 3',4',5,7-tetrahydroxy substitution) also resemble its anti-inflammatory activity. Isoorientin has been shown to possess significant anti-nociceptive and anti-inflammatory activities. Chlorogenic acid inhibits SE-induced T-cell proliferation and production of various pro-inflammatory compounds (e.g. IL-1β, TNF-α, IL-6, INF-γ, MCP-1, MIP-1α and MIP-1β) by human peripheral blood mononuclear cells and may serve as a potent anti-inflammatory agent. Antioxidant activity of the investigated extracts could be, at least partly, responsible for the observed anti-inflammatory effects, since it was earlier shown that antioxidants may mediate anti-inflammatory activity by direct scavenging of ROS, by influencing polymorphonuclear neutrophils oxidative metabolism and also by preventing induction of the cytokine cascade and up-regulating the expression of adhesion molecules " \\ |
