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--- capsella_bursa-pastoris_l._medik [2015/05/05 13:43]
andreas
+++ capsella_bursa-pastoris_l._medik [2015/05/05 13:46]
andreas
@@ Zeile 8: / Zeile 8: @@
 "Numerous physiologically active polypeptides have been found in animals and bacteria, but little has been reported about such substances in plants. A purified substance from an alcohol extract of the herb Capsella bursa-pastoris (Cruciferae), however, exerted contractile activity on the rat uterus which was similar to that of oxytocin and had some characteristics of a polypeptide." \\
 [Physiologically active substance in Capsella bursa-pastoris., Kuroda, K., Takagi, K., Nature 220, 1968, 707-708]
+"The treatment of ICR mice with i.p. injections (0.14 g/kg/day) of the extract of Capsella bursa-pastoris herb (Cruciferae) caused 50 to 80% inhibition of the solid growth of Ehrlich tumor cells that had been inoculated into the s.c. tissue of the animals. The tumor lumps in the treated mice showed multifocal necroses and the infiltration of host fibrous tissue cells. Experiments were also performed to isolate and identify the active component for the antitumor action, and an acidic substance was isolated in crystalline form from the herb extract. This acidic substance was identified as fumaric acid and was effective in inhibiting the growth of Ehrlich solid tumor at a dose of 10 mg/kg/day. The 50% lethal dose (i.p.) of this acid was 266 mg/kg. " \\
+[Inhibitory effect of Capsella bursa-pastoris extract on growth of Ehrlich solid tumor in mice., Kuroda, K., Akao, M., Kanisawa, M., Miyaki, K., Cancer research, Vol.36(6), 1976, 1900-1903]
 Nitrate content in the raw edible portion of wild C.bursa-pastoris species was found very high at 2.5g/kg fresh weight (in the range of celery, 2.3g, and spinach, 2.7g). \\

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